56例NSCLC脑转移灶与海马距离及与海马保护状态下PCI的PTV低剂量区关系

doi:10.3760/cma.j.issn.1004-4221.2016.01.011

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Abstract Objective To investigate the feasibility of prophylactic cranial irradiation with hippocampal avoidance (HA-PCI) in non-small cell lung cancer (NSCLC). Methods The clinical data of 56 patients with brain metastases of NSCLC who were treated from 2011 to 2014 were collected. Brain metastases and the hippocampus were delineated on T₁W1 contrast-enhanced MRI, and the distance between brain metastases and the hippocampus was analyzed;an HA-PCI regimen was also developed, and the distribution of the metastases in planning target volume (PTV) low-dose regions around the hippocampus was analyzed. Results None of the 139 metastases involved the hippocampus. There were 6(4.3%) and 18(12.9%) metastases within 5 mm and 10 mm, respectively, outside the hippocampus. In the HA-PCI regimen, the D_50% and D_2% of PTV were 25.6 Gy and 27.1 Gy, respectively. D_mean and D_2% for the hippocampus were 7.4 Gy and 9.9 Gy, respectively;D_50% within 0-5.0 mm, 5.1-10.0 mm, and 10.1-15.0 mm outside the hippocampus was 10.3 Gy, 15.1 Gy, and 20.5 Gy, respectively. Conclusions HA-PCI may be feasible theoretically, but this needs to be confirmed by the intracranial failure pattern in patients with long-term survival.

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Key words： Hippocampus avoidance Whole-brain radiotherapy Non-small cell lung cancer Brain metastases

Received: 04 January 2015

Corresponding Authors: Gu Wendong,Email:hony0428@126.com;Pei Honglei,Email:jtw316@sina.com

Cite this article:

. Distance between brain metastases of non-small cell lung cancer and the hippocampus and its correlation with PTV low-dose regions in prophylactic cranial irradiation with hippocampal avoidance:an analysis of 56 patients[J]. Chinese Journal of Radiation Oncology, 2016, 25(1): 42-45.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2016.01.011 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2016/V25/I1/42

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