鼻咽癌UICC第7版分期与中国2008分期比较及分期更新建议

doi:10.3760/cma.j.issn.1004-4221.2015.06.011

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Abstract Objective To compare the 7^th edition of International Union Against Cancer (UICC) staging system with the Chinese 2008 staging system for nasopharyngeal carcinoma (NPC), and to provide evidence for further updating of the staging system. Methods A retrospective analysis was performed among 767 patients who were pathologically and newly diagnosed with non-metastatic NPC and treated with intensity-modulated radiotherapy from 2006 to 2012. Based on the main prognostic indices, overall survival (OS), locoregional failure-free survival(LFFS)local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) rates, the value of T stage, N stage, and clinical stage in prognostic prediction was compared between the two staging systems. The Kaplan-Meier method was used for calculating survival rates. The log-rank test was used for survival difference analysis. The Cox model was used for multivariate prognostic analysis. Results In terms of T stage, the Chinese 2008 staging system was a significantly better predictor of the OS and LRFS rates than the 7^th edition of UICC staging system. In terms of N stage, they were comparable in the prediction of the OS and DMFS rates. In terms of clinical stage, the 7^th edition of UICC staging system was a significantly better predictor of the OS rate than the Chinese 2008 staging system. For the new staging system proposed based on the statistical results, the T, N, and clinical staging gave significantly better prognostic prediction. Conclusions The 7^th edition of UICC staging system and the Chinese 2008 staging system for NPC have their own advantages in prognostic prediction. The new staging system proposed in this study could contribute to the updating of the current staging system for NPC.

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	Articles by authors
	Liang Zhongguo
	Lei Hao
	Chen Zetan
	Li Ling
	Qu Song
	Su Fang
	Zhao Wei
	Pei Su
	Pan Xinbin
	Zhu Xiaodong

Key words： Nasopharyngeal neoplasmsm 7th union for international cancer control staging systems 2008 Chinese staging systems Comparison

Received: 01 June 2015

Corresponding Authors: Zhu Xiaodong,Email:zhuxdonggxmu@126.com

Cite this article:

Liang Zhongguo,Lei Hao,Chen Zetan et al. Comparison between the 7^th edition of International Union Against Cancer staging system and the Chinese 2008 staging system for nasopharyngeal carcinoma and suggestions for the updating of the staging system[J]. Chinese Journal of Radiation Oncology, 2015, 24(6): 653-658.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2015.06.011 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2015/V24/I6/653

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