3DCT、4DCT和PET-CT定义的胸段食管癌PTV比较研究

doi:10.3760/cma.j.issn.1004-4221.2015.05.005

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Abstract Objective To investigate the differences in position and volume between planning target volumes (PTV) based on positron emission tomography-computed tomography (PET-CT) images with an standardized uptake value (SUV) no less than 2.5, 20% of the maximum SUV (SUV_max), or 25% of SUV_max, three-dimensional (3D) CT, and four-dimensional (4D) CT in thoracic esophageal cancer. Methods Eighteen patients with thoracic esophageal cancer sequentially received chest 3DCT, 4DCT, and[18F]fluoro-2-deoxy-D-glucose (FDG) PET-CT scans. PTV_3D was obtained by conventional expansion of 3DCT images;PTV_4D was obtained by fusion of target volumes from 10 phases of 4DCT images. The internal gross tumor volumes (IGTV), IGTV_PET2.5, IGTV_PET20%, and IGTV_PET25%, were generated based on PET-CT images with an SUV no less than 2.5, 20% of SUV_max, and 25% of SUV_max, respectively. These IGTVs were expanded longitudinally by 3.5 cm and radically by 1 cm to make PTV_PET2.5, PTV_PET20%, and PTV_PET25%, respectively. Results PTV_3D was significantly larger than both PTV_4D and PTV_PET(P=0.000－0.044), while there was no significant difference between PTV_4D and PTV_PET(P=0.216－0.633). The mutual degrees of inclusion (DIs) between PTV_3D and PTV_4D were 0.70 and 0.95, respectively, which were negatively correlated with 3D-Vector (P=0.039). The mutual DIs between PTV_PET2.5, PTV_PET20%, and PTV_PET25% were 0.74, 0.72, 0.78, 0.73, 0.77, and 0.70, respectively, which showed no correlation with 3D-Vector (P=0.150－0.822). The mutual DIs between PTV_3D and PTV_PET were 0.86, 0.84, 0.88, 0.63, 0.67, and 0.59, respectively. Conclusions It is difficult to achieve complete volumetric overlap of PTVs based on 3DCT, 4DCT and PET-CT in thoracic esophageal cancer due to different target volume information. PET scan during free breathing should be used with caution to generate PTVs in thoracic esophageal cancer.

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	Guo Yanluan
	Li Jianbin
	Li Yankang
	Wang Wei
	Ma Zhifang
	Liang Chaoqian
	Xing Jun
	Duan Yili

Key words： Tomography,X-ray computed,three-dimensional Tomography,X-ray computed,four-dimensional Tomography, positron-emission, fluorodeoxyglucose Planning target volume Esophageal neoplasms/radiotherapy

Cite this article:

Guo Yanluan,Li Jianbin,Li Yankang et al. A comparative study of planning target volumes based on three-dimensional computed tomography, four-dimensional computed tomography, and positron emission tomography-computed tomography in thoracic esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2015, 24(5): 497-501.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2015.05.005 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2015/V24/I5/497

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