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Chinese Journal of Radiation Oncology  2013, Vol. 22 Issue (5): 411-413    DOI: 10.3760/cma.j.issn.1004-4221.2013.05.023
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Study the dosimetric for whole breast irradiation with fixed field IMRT and helical tomotherapy
YANG Bo,LIU Zhi-kai, HOU Xiao-rong, PANG Ting-tian,LI Wen-bo, LIU bo, SUN Hong-chang,HU Ke,QIU Jie,ZHANG Fu-quan.
Department of Radiotherapy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730,China
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Abstract  

Objective To compare the dosimetry difference between helical tomotherapy and fixed field IMRT for breast cancer radiotherapy after breast-conserving surgery. Methods Ten patients received radiotherapy after breast-conserving surgery were selected. For each patient, two treatment plans (FF-IMRT plan and HT plan) were designed with Eclipse and TomoTherapy. Same institutional dose-volume constraints for breast cancer were used in both techniques. Targets and organs at risk were compared with paired t-test for two planning. Results In comparison with the FF-IMRT planning, PTV coverage of HT plan group increased, Dmean became lower (P=0.000,0.002). the HI and CI were significantly higher for HT (P=0.001,0.023).Compared with the FF-IMRT plans, V5,V10,V20,V30,V40 and Dmean of the ipsilateral lung were reduced by about 28%,30%,35%,46%,61% and 32%(P=0.000),those of full lung were reduced by about 30%,28%,34%,46%,62% and 26%(P=0.000), those and Dmax of heart were reduced by about 57%,59%,71%,82%,91%,45% and 12%(P=0.000—0.002).The Dmean and Dmax of contralateral breast were higher by 0.9 Gy and 3.0 Gy (P=0.000,0.000) respectively, those of contralateral lung were higher by 0.42 Gy and 2.70 Gy (P=0.000,0.000) respectively. It takes significantly long time for the HT plans designed than FF-IMRT plan (11.98 min:5.96 min,P=0.000). Conclusions The HT planning improve the HI and CI of PTV, organs at risk can get equivalent or superior dose distribution compared with the FF-IMRT technology, but it is feasible for clinical applications in breast-conserving surgery as a new method.

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Articles by authors
YANG Bo
LIU Zhi-kai
HOU Xiao-rong
PANG Ting-tian
LI Wen-bo
LIU bo
SUN Hong-chang
HU Ke
QIU Jie
ZHANG Fu-quan.
Key wordsBreast neoplasms/fixed field intensity-modulated radiotherapy      Breast neoplasms/ helical tomotherapy      Dosimetry     
Received: 07 April 2013     
Corresponding Authors: QIU Jie,Email:qiujie@yahoo.cn   
Cite this article:   
YANG Bo,LIU Zhi-kai,HOU Xiao-rong et al. Study the dosimetric for whole breast irradiation with fixed field IMRT and helical tomotherapy[J]. Chinese Journal of Radiation Oncology, 2013, 22(5): 411-413.
YANG Bo,LIU Zhi-kai,HOU Xiao-rong et al. Study the dosimetric for whole breast irradiation with fixed field IMRT and helical tomotherapy[J]. Chinese Journal of Radiation Oncology, 2013, 22(5): 411-413.
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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.issn.1004-4221.2013.05.023     OR     http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2013/V22/I5/411
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