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An experimental study of 10 cGy whole brain radiation induced cognitive dysfunction
SUN Rui, ZHANG Li-yuan, JI Sheng-jun, CHEN Lie-song, JI Jian-feng, TIAN Ye
Department of Radiation Oncology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China Corresponding author:TIAN Ye, Email:dryetian@hotmail.com
Abstract Objective To investigate the relationship between 10 cGy whole brain radiation and cognitive dysfunction. Methods Thirty-two male Sprague-Dawley rats at age one month were randomized into irradiation and sham exposed groups. Behavioral and histopathological tests were performed 3 months after irradiation in the order of open field, Morris water maze, passive avoidance, and histopathological test. Comparison between the two groups was conducted using independent samples t-test. Results In the place navigation test of Morris water maze, irradiation group showed significantly longer latency than sham exposed group on day 3 and 4(t=2.91 and 2.65,all P<0.05). In the total latency of the place navigation, irradiation group also presented longer latency comparing with sham exposed group (t=2.63,P<0.05). In the spatial probe test of Morris water maze, the open field test and the passive avoidance test showed no significant difference between the two groups (t=0.92,0.59,0.83,all P>0.05).The histopathological examination had no significant difference either. Conclusion Whole brain radiation of 10 cGy could partly injury the cognitive function of the rat.
SUN Rui,ZHANG Li-yuan,JI Sheng-jun et al. An experimental study of 10 cGy whole brain radiation induced cognitive dysfunction[J]. Chinese Journal of Radiation Oncology, 2012, 21(5): 474-476.
SUN Rui,ZHANG Li-yuan,JI Sheng-jun et al. An experimental study of 10 cGy whole brain radiation induced cognitive dysfunction[J]. Chinese Journal of Radiation Oncology, 2012, 21(5): 474-476.
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2012, Vol. 21 
