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Prophylactic cranial irradiation for non-small cell lung cancer:a systematic review
BAI Ge*, GULIBIYE·Shabier, ZHANG Jian-qing, YANG Mei, BAO Yong-xing, ZHANG Li
*Department of Oncology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China Corresponding author:ZHANG Li,Department of Internal Medicine,First Affiliated Hospital,Xinjiang Medical Universty, Urumqi 830011,China;Email:zhangli9514@126.com
Abstract Objective To determine whether prophylactic cranial irradiation (PCI) has a role in the management of patients with non-small cell lung carcinoma (NSCLC) treated with radical intent. Methods We searched The Cochrane Library, MEDLINE, EMbase, CBM, CNKI and VIP. The quality of the included studies was critically evaluated. Data analyses were performed using the Cochrane Collaboration′s RevMan 5.1 software. Results Four randomized controlled trials involving 905 patients met the inclusion criteria. The results meta-analyses showed the incidence of brain metastases was lower in PCI group compared with the observation group (χ2=1.98,P=0.000);but there is no evidence of 1-year overall survival (OS) benefit (χ2=1.12,P=0.880).Only RTOG 2009 provides prospective data:There were no significant differences in global cognitive function (P=0.600) or ADL (P=0.880) after PCI, but there was a significant decline in immediate recall (P=0.030) and delayed recall (P=0.008) at 1 year. At 1 year, there was no significant differences in QOL after PCI (P=0.050). Conclusions This systematic review show significantly decreases the risk of BM without improving 1-year OS in NSCLC patient receiving prophylactic cranial irradiation. There is insufficient evidence to support the use of PCI in clinical practice. Where possible, patients should be offered entry into a clinical trial.
BAI Ge*,GULIBIYE·Shabier,ZHANG Jian-qing et al. Prophylactic cranial irradiation for non-small cell lung cancer:a systematic review[J]. Chinese Journal of Radiation Oncology, 2012, 21(5): 432-434.
BAI Ge*,GULIBIYE·Shabier,ZHANG Jian-qing et al. Prophylactic cranial irradiation for non-small cell lung cancer:a systematic review[J]. Chinese Journal of Radiation Oncology, 2012, 21(5): 432-434.
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2012, Vol. 21 
