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Correlation analysis between Naples prognostic score and treatment outcomes for locally advanced rectal cancer
Zhu Jiahao1, Gao Qizhong2, Guo Xinwei3, Liu Zhengcao4, Yang Bo1, Ji Shengjun4, Zhao Yutian1
1Department of Radiotherapy and Oncology, Affiliated Hospital of Jiangnan University, Wuxi 214000, China; 2Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, Wuxi 214000, China; 3Department of Radiotherapy and Oncology, Affiliated Taixing People's Hospital of Yangzhou University, Taixing 225400, China; 4Department of Radiotherapy and Oncology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China
AbstractObjective To analyze the correlation between the Naples prognostic score (NPS) after preoperative neoadjuvant chemoradiotherapy in locally advanced rectal cancer (LARC) and evaluate the prognostic value of NPS in LARC. Methods 136 patients with LARC meeting the recruitment criteria from 2015 to 2020 were selected. Serum albumin, total cholesterol (TC) were collected and neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio were calculated. All patients were scored and graded according to the NPS rule. The survival rate was calculated with Kaplan-Meier method. Multivariate prognostic analysis was performed by Cox models. Results There was no significant correlation between NPS score and tumor regression or pathological complete response (pCR) of LARC patients after neoadjuvant therapy (P=0.192, P=0.163). However, Cox multivariate analysis showed that NPS was an independent risk factor for overall survival (OS) and disease-free survival (DFS) of LARC (P=0.009, P=0.003), and hierarchical analysis suggested that LARC patients with lower NPS score obtained better prognosis. Besides NPS, tumor size was also an independent risk factor for OS, and tumor size and N stage were the independent risk factors for DFS. Conclusion NPS has no correlation with tumor regression or pCR for LARC after neoadjuvant chemoradiotherapy, whereas it could serve as an effective predictor for long-term prognosis of LARC.
Fund:Suzhou Cancer Clinical Medical Center Project (Szzx201506);Wuxi Science and Education Project (FZXK004)
Corresponding Authors:
Ji Shengjun, Email:happy168123@aliyun.com;Zhao Yutian, Email:13961730258@139.com
Cite this article:
Zhu Jiahao,Gao Qizhong,Guo Xinwei et al. Correlation analysis between Naples prognostic score and treatment outcomes for locally advanced rectal cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(12): 1256-1261.
Zhu Jiahao,Gao Qizhong,Guo Xinwei et al. Correlation analysis between Naples prognostic score and treatment outcomes for locally advanced rectal cancer[J]. Chinese Journal of Radiation Oncology, 2021, 30(12): 1256-1261.
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2021, Vol. 30 
