4D模板辅助<sup>125</sup>I粒子治疗晚期恶性肿瘤的剂量学研究

doi:10.3760/cma.j.cn113030-20201010-00492

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Abstract Objective To investigate the safety and dose of 4D template (real-time adjustable angle template) in the treatment of advanced malignant tumors with ¹²⁵I seeds. Methods 98 patients with advanced malignant tumors admitted to Department of Thoracic Surgery of Shaanxi Provincial Tumor Hospital were treated with 4D template-navigated radioactive ¹²⁵I seed implantation from June 2018 to December 2019. Preoperative TPS plan, intraoperative optimization, postoperative verification of immediate dose and postoperative evaluation of implantation dose were performed. The treatment results were observed. Results All 98 patients completed the seed implantation. The implantation dose of GTV of implantation site receiving external irradiation was (12489±414)cGy and the dose of no external irradiation was (15036±514)cGy. V100% was 84.7%-94.1%, and 88.2%-93.7%. The implantation dose of CTV was (7450±621)cGy,and (9080±761)cGy. The quality of dose implantation was evaluated as:excellent in 89 cases (91%, 89/98), good in 7 cases (7%, 7/98), fair in 2 cases (2%, 2/98), and poor in 0 case, respectively. The symptom relief rate of patients with pain was 92%(36/39). The 1-and 2-year local control rates were 61%, 36% and 82%, 54% in patients treated with and without external irradiation, respectively. The difference was statistically significant (P=0.02). The incidence rates of pneumothorax and hemoptysis were 19%(9/48) and 10%(5/48). No corresponding complications were observed in other parts of the patients. Conclusion 4D template-assisted ¹²⁵I seed therapy is safe and effective for malignant tumors, and intraoperative adjustment of needle angle and dose optimization can realize the precise control of implantation dose.

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	Articles by authors
	Liu Zhigang
	Lei Guangyan
	Song Yongchun
	Sun Ruifang
	Lyu Weidong
	Song Yangrong
	Zhang Xi
	Liu Jia
	Cheng Hao
	Han Le
	Zhao Kun
	Gao Wei
	Li Xiaolong
	Ning Xiaoju
	Qiang Libin

Key words： 4D template Real-time adjustable angle template Dosimetry Malignant neoplasm, advanced stage/¹²⁵I seed implantation

Received: 10 October 2020

Fund:National Natural Science Foundation of China (81802788);Shaanxi Provincial Natural Science Foundation (2018JM7028);Fundamental Research Funds for the Central Universities (xzy012020056)

Corresponding Authors: Lei Guangyan, Email:lei-g-y@163.com

Cite this article:

Liu Zhigang,Lei Guangyan,Song Yongchun et al. Dosimetric study of ¹²⁵I seed implantation guided by 4D template for advanced malignant tumors[J]. Chinese Journal of Radiation Oncology, 2022, 31(1): 55-58.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20201010-00492 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2022/V31/I1/55

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