食管癌放化疗后复发再程放疗的<i>Meta分析</i>

doi:10.3760/cma.j.cn113030-20200619-00312

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Abstract Objective To compare the efficacy and adverse events of salvage radiotherapy and other treatments for recurrent esophageal cancer after chemoradiotherapy in this Meta-analysis. Methods Databases including PubMed, Embase, Cochrane Library, CNKI and Wanfang data were searched from the inception to April 2020 to collect the clinical trials which comparatively analyzed the efficacy and safety between radiotherapy and other treatments for recurrent esophageal cancer after chemoradiotherapy. Meta-analysis was performed using RevMan 5.1 software. RR and 95%CI were used to describe the differences among different groups. Results According to the inclusion and exclusion criteria, a total of 11 clinical trials involving 842 patients were included. Meta-analysis showed that the overall survival in the salvage radiotherapy group was significantly lower than that in the salvage esophagectomy group (RR=0.40,95%CI:0.27-0.61,P<0.001), whereas significantly higher than that in the chemotherapy group (RR=2.91,95%CI:1.43-5.95,P=0.003). There was no significant difference in the treatment-related mortality between the salvage radiotherapy and salvage esophagectomy groups (RR=0.53,95%CI:0.14-1.98,P=0.350), but the incidence was significantly higher in the salvage esophagectomy group (1.7%-11.4% vs. 1.9%-2.8%). Conclusion Salvage radiotherapy is an effective treatment for recurrent esophageal cancer after chemoradiotherapy, which can be regarded as one choice for clinical patients.

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	Articles by authors
	Yu Wenhui
	Zhang Ping
	Zhen Chanjun
	Bai Wenwen
	Liu Sihan
	Chen Mingyue
	Zhou Zhiguo

Key words： Neoplasm recurrence, esophageal/chemoradiotherapy Neoplasm recurrence, esophageal/salvage esophagectomy Neoplasm recurrence, esophageal/salvage radiotherapy Meta-analysis

Received: 19 June 2020

Corresponding Authors: Zhou Zhiguo, Email:chenk777@126.com

Cite this article:

Yu Wenhui,Zhang Ping,Zhen Chanjun et al. Efficacy and safety of salvage radiotherapy for recurrent esophageal cancer after chemoradiotherapy:a Meta-analysis[J]. Chinese Journal of Radiation Oncology, 2021, 30(9): 892-897.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200619-00312 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2021/V30/I9/892

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