局部晚期食管鳞癌新辅助放疗剂量与病理完全缓解关系分析

doi:10.3760/cma.j.cn113030-20200301-00082

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Abstract Objective To investigate the relationship between the dose of preoperative neoadjuvant radiotherapy and the pathologic complete response (pCR) rate in patients with locally advanced squamous cell esophageal cancer (ESCC). Methods Clinical data of 116 patients with ESCC who received neoadjuvant chemoradiotherapy followed by esophagectomy in our cancer center from July 2017 to December 2019 were retrospectively analyzed. The radiation doses were divided into 2 ranges based on Grays (Gy) received:40-45 Gy and 45 Gy or more. Results The overall pCR rate was 38. 8%(45/116). pCR was observed in 35 out of 80(44%) patients treated with 40-45 Gy and 10 of 36(28%) patients treated with 45 Gy or more. The pCR rate did not significantly differ between two groups [(40-45 Gy) vs.( ≥ 45 Gy), P=0.105)]. Conclusions Preoperative neoadjuvant radiotherapy with a higher dose (≥ 45 Gy) fails to increase the pCR rate in patients with locally advanced ESCC. Prospective randomized trials are required to determine the optimal dose of preoperative adjuvant radiotherapy.

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	Articles by authors
	Zeng Xiaoxiao
	Sun Hongna
	Wei Hao
	Xu Yong
	Zhou Xiaojuan
	Ding Zhenyu
	Gong Youling
	Wang Jin
	Zhou Lin
	Lu You
	Yuan Yong
	Hu Yang
	Liu Yongmei

Key words： Esophageal neoplasm/neoadjuvant radiochemotherapy Dose of preoperative radiotherapy Pathologic complete response

Received: 01 March 2020

Fund:Health Commission of Sichuan Province（16ZD005）

Corresponding Authors: Liu Yongmei, Email:lymi75@163.com

Cite this article:

Zeng Xiaoxiao,Sun Hongna,Wei Hao et al. Relationship between adjuvant radiotherapy dose and pathologic complete response in patients with locally advanced esophageal squamous cell cancer[J]. Chinese Journal of Radiation Oncology, 2020, 29(8): 644-648.

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http://journal12.magtechjournal.com/Jweb_fszlx/EN/10.3760/cma.j.cn113030-20200301-00082 OR http://journal12.magtechjournal.com/Jweb_fszlx/EN/Y2020/V29/I8/644

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