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HT系统MVCT图像不同采集间距及配准条件对鼻咽癌放疗精度影响
何汇朗, 陈炫光, 刘慧, 许森奎, 林承光
510060 广州,华南国家肿瘤实验室 中山大学肿瘤防治中心放疗科
Effect of helical tomotherapy megavoltage CT under different acquisition pitch and registration conditions on the accuracy of radiotherapy for nasopharyngeal carcinoma
He Huilang, Chen Xuanguang, Liu Hui, Xu Senkui, Lin Chengguang
Department of Radiation Oncology,State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou 510060,China
Objective To evaluate the effect of helical tomotherapy (HT) megavoltage CT (MVCT) under different acquisition pitch and registration conditions upon the accuracy of radiotherapy for used nasopharyngeal carcinoma,aiming to provide reference for image-guided radiotherapy (IGRT) for nasopharyngeal carcinoma. Methods MVCT scans were performed on an anthropomorphic head& neck phantom which was simulated the positioning errors in the x,y and z direction. The obtained images were registered with the planning CT images. Acquisition pitch was set as the coarse,normal and fine modes. Registration conditions were set as bone registration,bone and soft tissue registration and full-image registration. Registration accuracy was determined by comparing the measured value with the preset value. The accuracy of radiotherapy under different acquisition pitch and registration conditions was statistically compared. Results The 3D errors of bone,bone and soft tissue and full-image registration under different acquisition pitch (coarse,normal and fine) were (1.51±0.47,1.54±0.35,1.81±0.53) mm and (1.41±0.37,1.53±0.36,1.56±0.39) mm and (1.51±0.27,1.57±0.32,1.73±0.33) mm,respectively. The bone registration yielded the highest accuracy (P<0.05).When the registration condition was set as bone registration,the accuracy of three acquisition pitch did not significantly differ (all P>0.05).The fine mode of acquisition pitch possessed the highest stability,whereas required the longest time. Conclusion The acquisition pitch and registration conditions should be selected during HT MVCT based on the clinical requirement of each patient with nasopharyngeal carcinoma.
He Huilang,Chen Xuanguang,Liu Hui et al. Effect of helical tomotherapy megavoltage CT under different acquisition pitch and registration conditions on the accuracy of radiotherapy for nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2018, 27(10): 930-932.
[1] Scrimger RA,Tomé WA,Olivera G H,et al. Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancer,in comparison to conventional field arrangements[J].J Clin Oncol,2003,26(1):70-78.
[2] 马林,王连元,周桂霞,等.肿瘤断层放射治疗[M].成都:四川科学技术出版社,2010:27-38.
Ma L,Wang LY,Zhou GX,et al. Tumor tomographic radiotherapy[M].Chengdu:Sichuan science and technology press,2010:27-38.
[3] Mohan R,Wu Q,Manning M,et al. Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiotherapy of head and neck cancers[J].Int J Radiat Oncol Biol Phys,2000,46(3):619-630.
[4] Balter JM,Chen GT,Pelizzari CA,et al. Online repositioning during treatment of the prostate:a study of potential limits and gains[J].Int J Radiat Oncol Biol Phys,1993,27(1):137-143.
[5] Astreinidou E,Bel A,Raaijmakers CPJ,et al. Adequate margins for random setup uncertainties in head-and-neck IMRT[J].Int J Radiat Oncol Biol Phys,2005,61(3):938-944.
[6] Zeidan O A, Langen K M, Meeks S L, et al. Evaluation of image-guidance protocols in the treatment of head and neck cancers[J].Int J Radiat Oncol Biol Phys,2007,67(3):670-677.
[7] Sharma SD,Dongre P,Mhatre V,et al. Evaluation of automated image registration algorithm for image-guided radiotherapy (IGRT)[J].Aust Phys Engi Sci Med,2012,35(3):311-319.
[8] 邹炼,侯氢.图像引导放疗中图像配准算法性质的研究[J].中华放射肿瘤学杂志,2008,17(5):381-384.DOI:10.3321/j.issn:1004-4221.2008.05.013.
Zou L,Hou H.Study on the properties of image registration algorithm in image guided radiotherapy[J].Chin J Radiat Oncol,2008,17(5):381-384.DOI:10.3321/j.issn:1004-4221.2008.05.013.
[9] 李晓玉,周继丹,钟仁明,等.千伏级CBCT引导鼻咽癌IMRT中不同图像配准方式比较[J].中华放射肿瘤学杂志,2014,23(4):340-343.DOI:10.3760/cma.j.issn.1004-4221.2014.04.016.
Li XY,Zhou JD,Zhong RM,et al. Comparison of different image registration methods in IMRT guided by kilovolt CBCT[J].Chin J Radiat Oncol,2014,23(4):340-343.DOI:10.3760/cma.j.issn.1004-4221.2014.04.016.
[10] 王猛,王远军.3种配准方式在鼻咽癌放射治疗过程中对配准结果的影响研究[J].生物医学工程与临床,2017(2):141-146.DOI:10.13339/j.cnki.sglc.20170309.007.
Wang M,Wang YJ.A study on the effect of 3 registration methods on registration results in radiotherapy of nasopharyngeal carcinoma[J].Biomed Engi Clin Appl,2017(2):141-146.DOI:10.13339/j.cnki.sglc.20170309.007.
2018, Vol. 27 
