Abstract:During the treatment of tumor,especially in head and neck cancer,oral mucositis is one of the common complications. The incidence of oral mucositis have relations with chemotherapy,targeted therapy,radiotherapy dose,radiotherapy technology and risk factors of patient. Severe oral mucositis may bring about treatment interrupted,decrease of tumor control rate,affect quality of life and so on. In general,what is very important during the treatment of tumor is to explore the prevention and treatment of oral mucositis.
Liu Mingzhu,Han Fei. Research progress of oral mucositis during the treatment of tumor[J]. Chinese Journal of Radiation Oncology, 2018, 27(9): 869-872.
[1] Sonis ST.Oral mucositis[J].Anti Drug,2011,22(7):607-612.DOI:10.1097/CAD.0b013e3283462086. [2] Elad S,Zadik Y,Yarom N.Oral complications of nonsurgical cancer therapies[J].Atlas Oral Maxillofac Surg Clin North Am,2017,25(2):133-147.DOI:10.1016/j.cxom.2017.04.006. [3] Crowder SL,Douglas KG,Pepino Y,et al. Nutrition impact symptoms and associated outcomes in post-chemoradiotherapy head and neck cancer survivors:a systematic review[J].J Cancer Surv,2018,12(4):479-494.DOI:10.1007/s11764-018-0687-7. [4] Tak A,Metgud R,Astekar M,et al. Micronuclei and other nuclear anomalies in normal human buccal mucosa cells of oral cancer patients undergoing radiotherapy:a field effect[J].Biotech Histochem,2014,89(6):464-9.DOI:10.3109/10520295.2014.904925. [5] Lockhart PB,Sonis ST.Alterations in the oral mucosa caused by chemotherapeutic agents.a histologic study[J].J Dermatol Surg Oncol,1981,7(12):1019-1025. [6] Balabanli B,Turkozkan N,Akmansu M,et al. Role of free radicals on mechanism of radiation nephropathy[J].Mol Cell Biochem,2006,293(1-2):183-186.DOI:10.1007/s11010-006-9240-5. [7] Bucci B,Misiti S,Cannizzaro A,et al. Fractionated ionizing radiation exposure induces apoptosis through caspase-3 activation and reactive oxygen species generation[J].Anti Res,2006,26(6B):4549-4557. [8] Ozben T.Oxidative stress and apoptosis:impact on cancer therapy[J].J Pharm Sci,2007,96(9):2181-2196.DOI:10.1002/jps.20874. [9] Ong ZY,Gibson RJ,Bowen JM,et al. Pro-inflammatory cytokines paly a key role in the development of radiothereapy-induced gastrointertinal mucositis[J].Radiat Oncol,2010,16(5):22.DOI:10.1186/1748-717X-5-22. [10] Logan RM,Stringer AM,Bowen JM,et al. Serum levels of NF-kappaB and Pro-inflammatore cytokines following administrsation of mucotoxic drugs[J].Cancer Biol Ther,2008,7(7):1139-1145. [11] Ferretti GA,Raybould TP,Brown AT,et al. Chlorhexidine prophylaxis for chemotherapy-and radiotherapy-induced stomatitis:a randomized double-blind trial[J].Oral Surg Oral Med Oral Pathol,1990,69(3):331-338. [12] Sonis ST.New thoughts on the initiation of mucositis[J].Oral Dis,2010,16(7):597-600.DOI:10.1111/j.1601-0825.2010.01681.x. [13] Peterson DE,Bensadoun RJ,Roila F,et al. Management of oral and gastrointestinal mucositis:ESMO Clinical Practice Guidelines[J].Ann Oncol,2011,22(6),78-84.DOI:10.1093/annonc/mdr391. [14] Elting LS,Keefe DM,Sonis ST,et al. Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy:demonstration of increased frequency,severity,resistance to palliation,and impact on quality of life[J].Cancer,2008,113(10):2704-2713.DOI:10.1002/cncr.23898. [15] Garg S,Yoo J,Winquist E.Nutritional support for head and neck cancer patients receiving radiotherapy:a systematic review[J].Support Care Cancer,2010,18(6):667-677.DOI:10.1007/s00520-009-0686-3. [16] Krishna SG,Zhao W,Grazziutti ML,et al. Incidence and risk factors for lower alimentary tract mucositis after 1529 courses of chemotherapy in a homogenous population of oncology patients:clinical and research implications[J].Cancer,2011,117(3):648-655.DOI:10.1002/cncr.25633. [17] Eilers RE Jr,Gandhi M,Patel JD,et al. Dermatologic infections in cancer patients treated with epidermal growth factor receptor inhibitor therapy[J].J Natl Cancer Inst,2010,102(1):47-53.DOI:10.1093/jnci/djp439. [18] Amitay-Laish I,David M,Stemmer SM.Staphylococcus coagulase-positive skin inflammation associated with epidermal growth factor receptor-targeted therapy:an early and a late phase of papulopustular eruptions[J].Oncologist,2010,15(9):1002-1008.DOI:10.1634/theoncologist.2010-0063. [19] Kajiya K,Sawane M,Huggenberger R,et al. Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis[J].J Invest Dermatol,2009,129(5):1292-1298.DOI:10.1038/jid.2008.351. [20] Malizzia LJ,Hsu A.Temsirolimus,an mTOR inhibitor for treatment of patients with advanced renal cell carcinoma[J].Clin J Oncol Nurs,2008,12(4):639-646.DOI:10.1188/08.CJON.639-646. [21] National Cancer Institute CTCAE[DB/OL][2018-06-23].http://evs.nci.nih.gov/ftp1/CTCAE/About.html. [22] Nagarajan K.Chemo-radiotherapy induced oral mucositis during IMRT for head and neck cancer-an assessment[J].Med Oral Patol Oral Cir Bucal,2015,20(3):e273-277.DOI:10.4317/medoral.20126. [23] Nonzee NJ,Dandade NA,Patel U,et al. Evaluating the supportive care costs of severe radiochemotherapy-induced mucositis and pharyngitis:results from a Northwestern University Costs of Cancer Program pilot study with head and neck and nonsmall cell lung cancer patients who received care at a county hospital,a Veterans Administration hospital,or a comprehensive cancer care center[J].Cancer,2008,113(6):1146-1152.DOI:10.1002/cncr.23714. [24] Peterson DE,Boers-Docts CB,Bensadoun RJ,et al. Management of oral and gastrointestinal mucosal injury:ESMO clinical practice guidelines for diagnosis,treatment,and follow-up[J].Ann Oncol,2015,26(5):139-151.DOI:10.1093/annonc/mdv202. [25] Hsiung CY,Ting HM,Huang HY,et al. Parotid-sparing intensity-modulated radiotherapy (IMRT) for nasopharyngeal careinoma:preserved parotid function after IMRT on quantitative.salivary scinmgrepny and comparison with historical data after conventional radiotherapy[J].Int J Radiat Oncol Biol Phys,2006,66(2):454-461.DOI:10.1016/j.ijrobp.2006.04.033. [26] Goyal M,Shukla P,Gupta D,et al. Oral mucositis in morning vs.evening irradiated patients:a randomised prospective study[J].Int J Radiat Biol,2009,85(6):504-509.DOI:10.1080/09553000902883802. [27] 侯春霞,孙晓峰,王金华.不同时相化疗不良反应的对比研究 [J].中华护理杂志,2000,35(12):723-727. [28] Lalla RV,Bowen J,Barasch A,et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy[J].Cancer,2014,120(10):1453-1461.DOI:10.1002/cncr.28592. [29] Oronsky B,Goyal S,Kim MM,et al. A review of clinical radioprotection and chemoprotection for oral mucositis[J].Transl Oncol,2018,11(3):771-778.DOI:10.1016/j.tranon.2018.03.014. [30] Kamran MZ,Ranjan A,Kaur N,et al. Radioprotective agents:strategies and translational advances[J].Med Res Rev,2016,36(3):461-493.DOI:10.1002/med.21386. [31] Weiss JF,Landauer MR.Protection against ionizing radiation by antioxidant nutrients and phytochemicals[J].Toxicology,2003,189(1-2):1-20.DOI.org/10.1016/S0300-483X (03)00149-5. [32] Koukourakis MI.Amifostine in clinical oncology:current use and future applications[J].Anti-Cancer Drugs,2007,13(3):181-209. [33] Calabro-Jones PM,Fahey RC,Smoluk GD,et al. Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721[J].Int J Radiat Biol Relat Stud Phys Chem Med,1985,47(1):23-27. [34] 黄惠明,张少群,卢妍等.口腔溃疡含漱液防治鼻咽癌放射性口腔黏膜炎的效果观察[J].护理与康复,2015,14(7):651-653.DOI:10.3969/j.issn.1671-9875.2015.07.016. [35] 黄光,林少民,符起亚等.口腔溃疡防护剂在防治鼻咽癌放射性口腔黏膜炎及对血清炎性因子影响的临床研究[J].中华放射肿瘤学杂志.2018,27(4):360-364.DOI:10.3760/cma.j.issn.1004-4221.2018.04.005. [36] Spivakovsky S.Oral cryotherapy reduced oral mucositis in patients having cancer treatments[J].Evid Based Dent,2016,17(3):80.DOI:10.1038/sj.ebd.6401186. [37] Arora H,Pai KM,Maiya A,et al. Efficacy of He-Ne Laser in the prevention and treatment of radiotherapy-induced oral mucositis in oral cancer patients[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2008,105(2):180-186.DOI:10.1016/j.tripleo.2007.07.043. [38] Fekrazad R,Chiniforush N.Oral mucositis prevention and management by therapeutic laser in head and neck cancers[J].J Lasers Med Sci,2014,5(1):1-7. [39] McGuire DB,Fulton JS,Park J,et al. Systematic review of basic oral care for the management of oral mucositis in cancer patients[J].Support Care Cancer,2013,21(11):3165-3177.DOI:10.1007/s00520-013-1942-0. [40] Roopashri G,Jayanthi K,Guruprasad R.Efficacy of benzydamine hydrochloride,chlorhexidine and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies:a drug trail[J].Contemp Clin Dent,2011,2(1):8-12.DOI:10.4103/0976-237X.79292. [41] Saunders DP,Epstein JB,Elad S,et al. Systematic review of antimicrobials,mucosal coating agents,anesthetics,and analgesics for the management of oral mucositis in cancer patients[J].Support Care Cancer,2013,21(11):3191-3207.DOI:10.1007/s00520-013-1871-y. [42] Clarkson JE,Worthington HV,Furness S,et al. Interventions for treating oral mucositis for patients with cancer receiving treatment[J/CD].Cochrane Database Syst Rev,2010,4(8):CD001973.DOI:10.1002/14651858.CD001973.pub4. [43] 顾红芳,黄灿红,葛方红等.双花百合片治疗放射性口腔黏膜炎40例疗效观察[J].交通医学,2014,28(6):673-677. [44] 王兆君,高力英.中医疗法治疗放射性口腔黏膜炎的研究进展[J].甘肃医学杂志,2017,36(7):547-549.DOI:10.15975/j.cnki.gsyy.2017.07.012. [45] Lin BM,Starmer HM,Gourin CG.The relationship between depressive symptoms,quality of life,and swallowing function in head and neck cancer patients 1 year after definitive therapy[J].Laryngoscope,2012,122(7):1518-1525.DOI:10.1002/lary.23312.