Effects of gross tumor volume and positive lymph node volume on prognosis of intensity-modulated radiotherapy for esophageal squamous cell carcinoma
Shi Xiangyu, Zhang Wencheng, Guan Yong, Qian Dong, Jiang Wei, Zeng Jing, Liu Xiaojie, Wang Daquan, Wang Jun, Wang Ping, Pang Qingsong
Department of Radiotherapy,Tianjin Huanhu Hospital,Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases,Tianjin 300350,China (Shi XY,Jiang W);Department of Radiotherapy,Cancer Hospital of Medical University of Tianjin,National Center for Clinical Oncology,Tianjin Key Laboratory of Cancer Prevention and Treatment,Tianjin 300060,China (Zhang WC,Guan Y,Qian D,Liu XJ,Wang DQ,Wang J,Wang P,Pang QS);Department of Gynecology and Oncology, Tianjin Central Obstetrics and Gynecology Hospital,Tianjin 300100,China (Zeng J)
Abstract：Objective To analyze the effects of gross tumor volume (GTV-T) and positive lymph node volume (GTV-LN) on the prognosis of radical concurrent chemoradiotherapy for esophageal squamous cell carcinoma (ESCC). Methods A total of 79 patients with stage N1 ESCC undergoing radical radiotherapy in our hospital from 2012 to 2015 were enrolled as subjects. GTV-T and GTV-LN were calculated by the Pinnacle3 9.0 treatment planning system. The receiver operating characteristic (ROC) curves were used to evaluate the value of the GTV-LN/GTV-T ratio in the prediction of local recurrence (LR) and distant metastasis (DM) of ESCC. Results The median follow-up time was 17.2 months in all patients. The ROC curves were made using the GTV-LN/GTV-T ratio. The optimal cut-off values of GTV-LN/GTV-T ratio for predicting the risk of LR and DM were 0.34 and 0.59, respectively. The statistical analysis revealed that the LR rates were 50% and 8% in patients with GTV-LN/GTV-T ratios of<0.34 and ≥0.34, respectively (P<0.01), while the DM rates were 11% and 43% in patients with GTV-LN/GTV-T ratios of<0.59 and ≥0.59, respectively (P=0.003). Conclusions The GTV-LN/GTV-T ratio may be a predictor of LR and DM in patients with ESCC. Further studies on the GTV-LN/GTV-T ratio may help to make personalized chemoradiotherapy strategies for patients with ESCC.
Shi Xiangyu,Zhang Wencheng,Guan Yong et al. Effects of gross tumor volume and positive lymph node volume on prognosis of intensity-modulated radiotherapy for esophageal squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2017, 26(12): 1389-1393.
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