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肺寡转移瘤SBRT疗效及预后因素分析
李智军,李春阳,张俊红,王骁踊,张俊,王大奖,钟亚华,周福祥,周云峰,谢丛华
430071 武汉大学中南医院放化疗科 湖北省肿瘤医学临床研究中心
Clinical efficacy and prognostic factors of stereotactic body radiotherapy for pulmonary oligometastases
Li Zhijun, Li Chunyang, Zhang Junhong, Wang Xiaoyong, Zhang Jun, Wang Dajiang, Zhong Yahua, Zhou Fuxiang, Zhou Yunfeng, Xie Conghua
Department of Radiation and Medical Oncology,Zhongnan Hospital,Wuhan University,Hubei Key Laboratory of Tumor Biological Behaviors,Wuhan University,Wuhan 430071,China
Objective To evaluate the clinical efficacy and prognostic factors of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases, and to further explore the patients most suitable for SBRT. Methods From 2012 to 2105, 51 patients with 76 oligometastatic lung tumors were treated with SBRT. In those patients, 27 had primary lung tumors and the others had extrapulmonary tumors. Seven patients had squamous cell carcinoma, thirty-five had adenocarcinoma, and the rest had other types of cancer. The patients received radiotherapy at a dose of 50 Gy in five fractions or 60 Gy in three fractions. Survival analysis was made by the Kaplan-Meier method. A multivariate analysis was made by the Cox model. Results The 1-and 2-year local control rates were 86%(65/76) and 80%(61/76), respectively. The 1-and 2-year overall survival (OS) rates were 80%(41/51) and 55%(28/51), respectively. The median survival time was 30(2-57) months, while the median progression-free survival time was 8(1-32) months. Twenty-one patients had grade 1 radiation pneumonitis (RP), while one patient had grade 2 RP. The multivariate analysis revealed that no more than 2 oligometastatic lung tumors, progression-free interval (PFI), and a performance score (PS) no higher than 1 were independent factors for OS (all P<0.05). Conclusions SBRT is effective and safe for treating pulmonary oligometastases. The number of oligometastatic lung tumors, PFI, and PS are independent prognostic factors for OS. Suitable patients and the appropriate timing of treatment are key to the efficacy of SBRT.
Li Zhijun,Li Chunyang,Zhang Junhong et al. Clinical efficacy and prognostic factors of stereotactic body radiotherapy for pulmonary oligometastases[J]. Chinese Journal of Radiation Oncology, 2017, 26(12): 1381-1384.
[1] Ramalingam S,Belani C.Systemic chemotherapy for advanced non-small cell lung cancer:recent advances and future directions[J].Oncologist,2008,13(S1):5-13.DOI:10.1634/theoncologist.13-S1-5.
[2] Shultz DB,Filippi AR,Thariat J,et al. Stereotactic ablative radiotherapy for pulmonary oligometastases and oligometastatic lung cancer[J].J Thorac Oncol,2014,9(10):1426-1433.DOI:10.1097/JTO.0000000000000317.
[3] Bansal P,Rusthoven C,Boumber Y,et al. The role of local ablative therapy in oligometastatic non-small-cell lung cancer:hype or hope[J].Future Oncol,2016,12(23):2713-2727.DOI:10.2217/fon-2016-0219.
[4] 江雪,严森祥,徐秋一,等.肿瘤寡转移及其治疗策略[J].国际肿瘤学杂志,2013,40(8):584-586.DOI:10.3760/cma.j.issn.1673-422X.2013.08.008.
Jiang X,Yan SX,Xu QY,et al. Neoplasm oligometastasis and its therapeutic strategies[J].J Int Oncol,2013,40(8):584-586.DOI:10.3760/cma.j.issn.1673-422X.2013.08.008.
[5] Salama JK,Hasselle MD,Chmura SJ,et al. Stereotactic body radiotherapy for multisite extracranial oligometastases:final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease[J].Cancer,2012,118(11):2962-2970.DOI:10.1002/cncr.26611.
[6] Pastorino U,Buyse M,Friedel G,et al. Long-term results of lung metastasectomy:prognostic analyses based on 5206 cases[J].J Thorac Cardiovasc Surg,1997,113(1):37-49.DOI:10.1016/S0022-5223(97)70397-0.
[7] Chua TC,Saxena A,Liauw W,et al. Hepatic resection for metastatic breast cancer:a systematic review[J].Eur J Cancer,2011,47(15):2282-2290.DOI:10.1016/j.ejca.2011.06.024.
[8] Nanji S,Cleary S,Ryan P,et al. Up-front hepatic resection for metastatic colorectal cancer results in favorable long-term survival[J].Ann Surg Oncol,2013,20(1):295-304.DOI:10.1245/s10434-012-2424-1.
[9] House MG,Ito H,Gönen M,et al. Survival after hepatic resection for metastatic colorectal cancer:trends in outcomes for 1,600 patients during two decades at a single institution[J].J Am Coll Surg,2010,210(5):744-752.DOI:10.1016/j.jamcollsurg.2009.12.040.
[10] Pfannschmidt J,Dienemann H.Surgical treatment of oligometastatic non-small cell lung cancer[J].Lung Cancer,2010,69(3):251-258.DOI:10.1016/j.lungcan.2010.05.003.
[11] Durante M,Reppingen N,Held KD.Immunologically augmented cancer treatment using modern radiotherapy[J].Trends Mol Med,2013,19(9):565-582.DOI:10.1016/j.molmed.2013.05.007.
[12] Press RH,Boselli DM,Symanowski JT,et al. External validity of a risk stratification score predicting early distant brain failure and salvage whole brain radiation therapy after stereotactic radiosurgery for brain metastases[J].Int J Radiat Oncol Biol Phys,2017,98(3):632-638.DOI:10.1016/j.ijrobp.2017.03.012.
[13] Guerrero E,Ahmed M.The role of stereotactic ablative radiotherapy (SBRT) in the management of oligometastatic non small cell lung cancer[J].Lung Cancer,2016,92:22-28.DOI:10.1016/j.lungcan.2015.11.015.
[14] Soyfer V,Corn BW,Shtraus N,et al. Single-institution experience of SBRT for lung metastases in sarcoma patients[J].Am J Clin Oncol,2017,40(1):83-85.DOI:10.1097/COC.0000000000000103.
[15] Sun B,Brooks ED,Komaki R,et al. Long-term outcomes of salvage stereotactic ablative radiotherapy for isolated lung recurrence of non-small cell lung cancer:a phase Ⅱ clinical trial[J].J Thorac Oncol,2017,12(6):983-992.DOI:10.1016/j.jtho.2017.02.018.
[16] Ricardi U,Filippi AR,Guarneri A,et al. Stereotactic body radiation therapy for lung metastases[J].Lung Cancer,2012,75(1):77-81.DOI:10.1016/j.lungcan.2011.04.021.