应用真空负压垫联合热塑体膜对小儿肾母细胞瘤放疗价值

doi:10.3760/cma.j.issn.1004-4221.2017.08.018

摘要
图/表
参考文献()
相关文章 (15)
点击分布统计
下载分布统计

全文: PDF (1093 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS) 背景资料

摘要目的探讨真空负压垫联合热塑体膜在小儿肾母细胞瘤放疗中的临床应用价值。方法选取 42例肾母细胞瘤术后接受放疗的小儿患者,依据体位固定方式的不同将其等分成A、B组,A组患者在放疗实施时采用真空负压垫固定体位,B组患者则采用真空负压垫联合热塑体膜固定体位。对比两组患者在治疗时的摆位误差、近期效果、不良反应以及预后。对计数资料行χ²检验,计量资料行t检验。结果在平移误差、旋转误差、≤3 mm和≤5 mm的对比中B组均小于A组(P=0.04、0.04、0.04、0.03、0.00、0.04、0.04、0.00、0.04);B组的完全缓解率、有效率均好于A组(P=0.02、0.04);A组和B组的不良反应发生率相近(P=0.75);A组和B组在2、3年OS率相近(P=0.68、0.74)。A组和B组在左右、头脚、腹背向外放值分别为5.74、5.93、5.94 mm和4.21、5.71、4.61 mm。结论对小儿肾母细胞瘤患者放疗时采取真空负压垫联合热塑体膜体位固定技术可降低摆位误差,提高放疗效果,值得在临床工作中推广和应用。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	屈超
	韩晨

关键词 ：肾母细胞瘤/放射疗法, 真空负压垫, 热塑体膜, 治疗效果, 不良反应

Abstract： Objective To investigate the clinical value of negative pressure vacuum cushion combined with thermoplastic body membrane in radiotherapy for Wilms tumor in children. Methods A total of 42 pediatric patients with Wilms tumor who received radiotherapy after surgery were enrolled in the study and were randomly divided into two groups according to the fixation positions:group A and group B. During radiotherapy, the patients in group A were fixed with negative pressure vacuum cushion, and those in group B were fixed by negative pressure vacuum cushion combined with thermoplastic body membrane. The setup errors, short-term effects, adverse reactions, and prognosis were compared between the two groups. Results Group B showed significantly lower translational errors and rotational errors, as well as significantly higher rates of ≤3 mm and ≤5 mm errors, compared with the group A (P=0.04,0.04,0.04,0.03,0.00,0.04,0.04,0.00,0.04). Group B also showed significantly higher complete remission rates and response rates than group A (P=0.02,0.04). There were no significant differences in the adverse reaction rates (P=0.75) and the overall survival (OS) rates at 2 and 3 years (P=0.68,0.74) between the two groups. Group A had the M_PTV values in left-right (LR) direction (x-axis), superior-inferior (SI) direction (y-axis), and anterior-posterior (AP) direction (z-axis) being 5.74 mm, 5.93 mm, and 5.94 mm, respectively, and group B had the M_PTV values at LR, SI, and AP directions being 4.21 mm, 5.71 mm, and 4.61 mm, respectively. Conclusions In the radiotherapy positioning for Wilms tumor in children, fixation limbs with negative pressure vacuum cushion combined with thermoplastic body membrane effectively reduces the setup errors and improves the effect of radiotherapy, so it holds promise for clinical application.

Key words： Wilms tumor/radiotherapy Vacuum negative pressure pad Thermoplastic body membrane Treatment effect Adverse reaction

收稿日期: 2016-08-17

引用本文:

屈超,韩晨. 应用真空负压垫联合热塑体膜对小儿肾母细胞瘤放疗价值[J]. 中华放射肿瘤学杂志, 2017, 26(8): 934-937.

Qu Chao,Han Chen. Clinical value of negative pressure vacuum cushion combined with thermoplastic body membrane in radiotherapy for Wilms tumor in children[J]. Chinese Journal of Radiation Oncology, 2017, 26(8): 934-937.

链接本文:

http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2017.08.018 或 http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2017/V26/I8/934

[1] 杨静薇,蒋慧,陆正华,等.儿童肾母细胞瘤个体化综合治疗的疗效分析[J].上海交通大学学报(医学版),2011,31(6):817-820.
Yang JW,Jiang H,Lu ZH,et al. Analysis of curative effect of nephroblastoma individualized comprehensive treatment[J].J Shanghai Jiao Tong Uni (Med Sci Ed),2011,31(6):817-820.
[2] 赵卫红,华瑛,卢新天,等.小儿肾母细胞瘤综合治疗的长期疗效[J].实用儿科临床杂志,2010,25(23):1786-1787.
Zhao WH,Hua Y,Lu XT,et al. The long-term curative effect of comprehensive treatment in nephroblastoma[J].J App Clin Pediat,2010,25(23):1786-1787.
[3] Eisenhauer EA,Therasse P,Bogaerts J,et al. New response evaluation criteria in solid tumors:revised RECIST guideline (version 1.1)[J].Eur J Cancer,2009,45(2):228-247.DOI:10.1016/j.ejca.2008.10.026.
[4] Watanabe H,Okada M,Kaji Y,et al. New response evaluation criteria in solid tumors-revised RECIST guideline (version 1.1)[J].Can To Kagaku Ryoho,2009,36(12):2495-2501.
[5] Trotti A,Colevas AD,Setser A,et al. CTCAE v3.0:development of a comprehensive grading system for the adverse effects of cancer treatment[J].Semin Radiat Oncol,2003,13(1):176-181.
[6] Palazzi M,Tomatis S,Orlandi E,et al. Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer:prospective observational study validating CTCAE,version 3.0,scoring system[J].Int J Radiat Oncol Biol Phys,2008,70(2):330-337.
[7] Van Herk M,Remeijer P,Rasch C,et al. The probabitlity of correct target dosage:Dose-population histograms for deriving treatment margins in radiotherapy[J].Int Radiat Oncol Biol Phys,2000,47(4):1121-1135.
[8] Hurkmans CW,Remeijer P,Lebesque JV,et al. Setup verification using portal imaging;review of current clinical practice[J].Radiother Oncol,2001,58(2):105-120.
[9] 李欣,安玉,杨志勇.儿童肾母细胞瘤的CT诊断[J].中华放射学杂志,1998,32(3):185-187.
Li X,An Y,Yang ZY.CT diagnosis of nephroblastoma in children[J].Chin J Radiol,1998,32(3):185-187.
[10] 许涛,景红霞,李林均.肾母细胞瘤的研究进展[J].现代肿瘤学,2015,23(13):1928-1931.
Xu T,Jing HX,Li LJ.Research progress of nephroblastoma[J].Mod Oncol,2015,23(13):1928-1931.