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放射性肺损伤与Th1/Th2免疫失衡研究进展
程静，姚晔，谢丛华
430071 武汉大学中南医院放化疗科肿瘤生物学行为湖北省重点实验室肿瘤学湖北省临床研究中心
Research advances in radiation-induced lung injury and Th1/Th2 imbalance
Cheng Jing,Yao Ye,Xie Conghua
Department of Radiation and Medical Oncology,Zhongnan Hospital,Wuhan University,Hubei Key Laboratory of Tumor Biological Behaviors,Zhongnan Hospital,Wuhan University,Wuhan 430071,China
Abstract： Normal lung tissues are inevitably exposed to X-ray in thoracic radiotherapy, causing radiation-induced lung injury (RILI). The main pathological manifestations include the accumulation of inflammatory cells, release of cytokines, accumulation and proliferation of fibroblasts, and excessive deposition of alveolar interstitial collagen in the irradiated region. RILI severely affects the treatment compliance and quality of life and even threatens the life in the patients receiving radiotherapy. In recent years, numerous studies have found that Th1/Th2 imbalance is closely associated with the development and progression of RILI, and the cytokine network plays an executive role in the progression of RILI. Therefore, restoring the Th1/Th2 balance in vivo may provide a new way to prevent and treat RILI.
Cheng Jing,Yao Ye,Xie Conghua. Research advances in radiation-induced lung injury and Th1/Th2 imbalance[J]. Chinese Journal of Radiation Oncology, 2017, 26(6): 706-710.
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