Research advances in subventricular zone irradiation in glioblastoma
Wang Chengang,Luo Yijun,Li Minghuan,Yu Jinming
School of Medicine and Life Sciences,University of Ji’nan,Shandong Academy of Medical Sciences,Ji’nan 250000,China (Wang CG,Luo YJ);Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Ji’nan 250117,China (Wang CG,Luo YJ,Li MH,Yu JM)
Abstract： Glioblastoma multiforme (GBM, WHO grade IV) contains some glioma stem cells which have unique self-renewal capacity and multilineage potency. There are numerous neural stem cells in the subventricular zone (SVZ) of adult human brain;it may also act as a storehouse of glioma stem cells that can promote the development and recurrence of a tumor. GBM involving SVZ is prone to early recurrence and intracranial metastasis after resection, so irradiation of the SVZ potentially influences the survival of GBM patients. This review provides a summary of related experimental and clinical studies, and discusses the value of irradiation of the SVZ in GBM patients and the direction of future research.
Wang Chengang,Luo Yijun,Li Minghuan et al. Research advances in subventricular zone irradiation in glioblastoma[J]. Chinese Journal of Radiation Oncology, 2017, 26(6): 702-705.
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2017, Vol. 26 
