Department of Radiation Oncology,National Cancer Center/Cancer Hospital,Chinese Academy-of Medical Sciences,Peking Union Medical College,Beijing 100021,China
Abstract： Objective To evaluate the risk of locoregional recurrence (LRR) and the influencing factors for long-term survival in patients with inflammatory myofibroblastic tumor (IMT). Methods A retrospective analysis was performed for 58 IMT patients who completed initial therapy or initial adjuvant therapy in our hospital from January 2002 to January 2017 to evaluate their failure patterns and survival. The LRR and survival rates were compared between groups. The Kaplan-Meier method was used to calculate survival rates,and the log-rank test was used for survival difference analysis and univariate prognostic analysis. Results The median follow-up time was 34 months. Among the 58 patients,50 underwent surgery alone,and 8 underwent surgery and adjuvant therapy. Seventeen patients experienced treatment failure,16 patients developed LRR,3 patients developed distant metastasis,including 2 patients with local failure,and 5 patients died of tumor recurrence or metastasis. The 5-year LRRFS was 75%,and the 5-year OS rate was 90%.The univariate analysis showed that resection margin and local staging were influencing factors for LRRFS (P=0.018,0). Conclusions Radical resection combined with adjuvant therapy is the key to improving the treatment outcome of IMT.
Zhang Jianghu,Gao Li,Yi Junlin et al. Clinical features and treatment outcome of inflammatory myofibroblastic tumor:a retrospective study of 58 patients[J]. Chinese Journal of Radiation Oncology, 2017, 26(6): 646-649.
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