Wenzhou Medical University,Wenzhou 325032,China(Dong BQ);Department of Radiation Oncology,Zhejiang Key Lab of Radiation Oncology,Zhejiang Cancer Hospital,Hangzhou 310022,China
Abstract： Objective To evaluate the safety and clinical efficacy of stereotactic body radiation therapy (SBRT) for lung cancer. Methods A retrospective analysis was performed on 200 patients with primary non-small cell lung cancer (NSCLC)(118 patients) or solitary pulmonary metastasis (82 patients) who underwent SBRT in Zhejiang Cancer Hospital from January 2012 to September 2015. The 80% isodose line covered 95% of the planning target volume, and the 100% isodose line covered 100% of the internal gross tumor volume. The fractional dose was 4.0-18.0 Gy daily or every other day, and the biologically equivalent dose ranged from 40.0 to 151.2 Gy (median 100 Gy). Results All patients completed treatment. The follow-up rate was 96.0%. The complete response and partial response rates were 14.8%(17/115) and 65.2%(75/115) for the primary tumor group, versus 25%(19/77) and 38%(29/77) for the metastasis group. The incidence rates of grade Ⅱ and Ⅲ acute radiation pneumonitis were 4.7% and 3.1%, respectively. The median follow-up was 14.9 months. The 1-and 2-year local control rates were 95.7% and 84.3% for the primary tumor group, versus 92% and 73% for the metastasis group. The 1-and 2-year overall survival rates were 94.5% and 92.0% for the primary tumor group, versus 85% and 62% for the metastasis group. Conclusions SBRT is a safe and effective treatment for early primary NSCLC and solitary pulmonary metastasis, resulting in high 1-and 2-year local control and overall survival rates and low rate of complications.
Dong Baiqiang,Xu Yujin,Sun Xiaojiang et al. Experience and efficacy of SBRT for lung cancer:an analysis of 200 patients[J]. Chinese Journal of Radiation Oncology, 2017, 26(6): 627-630.
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