Clinical efficacy and safety of recombinant adenovirus-p53 combined with concurrent radiotherapy and hyperthermia in treatment of advanced soft tissue sarcoma:a study of 76 patients
Department of Radiotherapy,Key laboratory of Carcinogenesis and Translational Research (Ministry of Education),Beijing University Cancer Hospital& Institute,Beijing 100142,China
Objective To evaluate the efficacy and safety of recombinant adenovirus-p53(rAdp53) injection combined with radiotherapy and hyperthermia in the treatment of unresectable advanced soft tissue sarcoma.Methods In this retrospective study, we evaluated 76 patients with unresectable advanced primary or recurrent soft tissue sarcoma treated in our hospital from November 2005 to November 2012. These patients received radiotherapy and hyperthermia with rAdp53(p53 group, n=41) or without rAdp53(control group, n=35). rAdp53((1-2)×1012 viral particles each time, once a week, 8 times on average) was injected into the tumor or infused into the pelvic cavity. Radiotherapy (2 Gy each time, 5 times a week) was performed for the planning target volume at 56.3±5.3 Gy in the p53 group and 58.1±4.2 Gy in the control group, with no significant difference between the two groups (P>0.05). Superficial or deep thermotherapy was employed 8 times on average (twice a week). Clinical features, response rate, time to progression (TTP), overall survival (OS), and adverse events were compared between the two groups (P>0.05). The Kaplan-Meier method was used to calculate OS;the log-rank test was used for survival difference analysis and univariate prognostic analysis;the chi-square test was used for comparison of categorical data. Results At 2 months after treatment, the p53 group had significantly increased response rate (partial response+ complete response+ stable disease)(85% vs. 54%, P=0.003) and local control rate (49% vs. 23%, P=0.020) as well as prolonged TTP (12 months vs. 5 months, P=0.010) and OS (48 months vs. 31 months, P=0.049), as compared with the control group. No adverse events caused by radiotherapy and hyperthermia except transient fever were seen in the two groups. Conclusions Concurrent radiotherapy and hyperthermia combined with rAdp53 injection is effective and safe for patients with advanced soft tissue sarcoma.
Xiao Shaowen,Xu Yizhi,Zhang Shanwen et al. Clinical efficacy and safety of recombinant adenovirus-p53 combined with concurrent radiotherapy and hyperthermia in treatment of advanced soft tissue sarcoma:a study of 76 patients[J]. Chinese Journal of Radiation Oncology, 2017, 26(5): 546-549.
2017, Vol. 26 
