Expert consensus on work flow and quality control of CT-guided 125I seed permanent interstitial brachytherapy assisted by 3D-printing non-coplanar templates
Radiation Oncology Branch of Chinese Medical Association,Radiotherapy Specialized of China Physicians Committee,Radiotherapy Specialized of China Research Hospital Committee,Minimally Invasive Treatment Branch of China Elderly Cancer Society,Chinese North Multi Center Cooperative Group of Particles Radiotherapy Specialized of Beijing Medical Association
Abstract： Permanent radioactive seed implantation belongs to the interstitial brachytherapy which delivers a high dose to the target volume and low doses to the surrounding normal tissues. Seed implantations are under puncture guidance which leads to minimal injury and rapid recovery, thus becoming the standard therapy for early-stage prostate carcinoma. Radioactive seed implantations require the guidance by ultrasound, CT, and MRI assisted by the navigator system to ensure accurate seed distribution in the target volume and a high degree of consistency with preoperative planning. To realize a conformal and precise dose distribution in the target volume, image guidance with template assistance is the key. 125I seed implantation under ultrasound guidance with transperineal template assistance has become a very successful therapy for prostate carcinoma, but no criteria are available for its use in other carcinomas. Here we review the consensus on the 125I seed implantation therapy under CT-guidance assisted by 3D-printing non co-planar template (3D-PNCT), including radiation physics and dosimetry, indications, and 3D-PNCT work flow. Despite the effectiveness of 125I seed implantation as a local therapy for solid tumors, there is still a compelling need for prospective, randomized, multi-center clinical trials to get high-level evidence to confirm the role of 125I seed implantation in the comprehensive treatment of cancer.
. Expert consensus on work flow and quality control of CT-guided 125I seed permanent interstitial brachytherapy assisted by 3D-printing non-coplanar templates[J]. Chinese Journal of Radiation Oncology, 2017, 26(5): 495-500.
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