Abstract：Objective To analyze the outcomes and prognostic factors in patients with esophageal cancer after concurrent chemoradiotherapy. Methods A total of 135 patients with esophageal squamous cell carcinoma were enrolled in the clinical study from January 2008 to June 2015. The patients were treated with two-dimensional radiotherapy (56 patients) or three-dimensional radiotherapy (79 patients). The radiotherapy was delivered at a total dose of 60-64 Gy (1.8-2.0 Gy per fraction). The concurrent chemotherapy regimen consisted of fluorouracil plus cisplatin or paclitaxel plus cisplatin and was performed on days 1 and day 29 of radiotherapy. The Kaplan-Meier method was used to calculate overall survival (OS) and progression-free survival (PFS) rates, the log-rank test was used for survival difference analysis andunivariate prognostic analysis, and the Cox model was used for multivariate prognostic analysis. Results The 1-, 3-, and 5-year sample sizes were 96,31,16, respectively. The 1-, 3-, and 5-year OS rates were 74.0%, 39.0%, and 28.6%, respectively;the median OS time was 25 months. The 1-, 3-, and 5-year PFS rates were 57.3%, 27.3%, and 16.6%, respectively;the median PFS time was 15 months. The univariate analysis indicated that clinical stage, radiotherapy method, and M stage were prognostic factors for OS and PFS (P=0.006, 0.000, and 0.032;P=0.017, 0.004, and 0.000). The multivariate analysis showed that clinical stage and radiotherapy method were independent prognostic factors for OS and PFS (P=0.006 and 0.000;P=0.033 and 0.023). Conclusions For non-surgical treatment of patients with esophageal cancer, concurrent chemoradiotherapy is a preferred strategy and has proven to be effective and tolerable.
Wang Xiushen,Zhang Xiqian,Liu Xiao et al. Analysis of outcomes and prognostic factors in patients with esophageal cancer after concurrent chemoradiotherapy[J]. Chinese Journal of Radiation Oncology, 2017, 26(4): 400-404.
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