Current research on molecular mechanism of ionizing radiation-induced neurogenesis disorders
Huang Ping, Zhang Liyuan, Yang Hongying, Tian Ye
Department of Radiotherapy and Oncology,Second Affiliated Hospital,Institute of Radiation Oncology,Soochow University; Suzhou Key Laboratory of Radiation Oncology;Suzhou Medical Center for Radiation Oncology,Suzhou 215004,China (Huang P,Zhang LY,Tian Y); Jiangsu Collaborative Innovation Center of Radiation Medicine; Department of Radiation Medicine and Protection,Soochow University School of Medicine; Suzhou 215123,China (Yang HY)
Abstract：With the development of modern radiotherapy techniques, radiotherapy has been widely used in the multimodality therapy for various malignant tumors, including head and neck cancers such as nasopharyngeal cancer and laryngeal cancer. A combination of surgery and radiochemotherapy significantly improves patients’ cure rate and survival time;however, with the increase in survival time, some patients receiving radiotherapy develop marked cognitive impairment. Ionizing radiation-induced cognitive impairment mainly manifests as hippocampus-dependent cognitive impairment, which is associated with inhibited hippocampal neurogenesis due to ionizing radiation. Therefore, it is necessary to investigate the mechanisms of the inhibition of hippocampal neurogenesis by ionizing radiation. This article reviews the molecular mechanism of neurogenesis disorders induced by ionizing radiation.
Huang Ping,Zhang Liyuan,Yang Hongying et al. Current research on molecular mechanism of ionizing radiation-induced neurogenesis disorders[J]. Chinese Journal of Radiation Oncology, 2017, 26(4): 481-484.
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