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中华放射肿瘤学杂志
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中华放射肿瘤学杂志  2016, Vol. 25 Issue (9): 934-938    DOI: 10.3760/cma.j.issn.1004-4221.2016.09.005
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术后辅助放疗对局限期软组织肉瘤疗效影响
赵如平,俞晓立,章真,冯炎,杨昭志,王坚,郭小毛
310002 杭州市肿瘤医院放疗科(赵如平);200032上海,复旦大学上海医学院肿瘤学系复旦大学附属肿瘤医院放疗科(俞晓立、章真、冯炎、杨昭志、王坚、郭小毛)
Effect of postoperative adjuvant radiotherapy on treatment outcome of patients with localized soft tissue sarcoma
Zhao Ruping,Yu Xiaoli,Zhang Zhen,Feng Yan,Yang Zhaozhi,Wang Jian,Guo Xiaomao
Department of Radiation Oncology,Hangzhou Cancer Hospital,Hangzhou 310002 China (Zhao RP);Department of Radiation Oncology,Cancer Hospital of Fudan University,Department of Oncology,Shanghai Medical College of Fudan University,Shanghai 200032,China (Yu XL,Zhang Z,Feng Y,Yang ZZ,Wang J,Guo XM)
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摘要 目的 评价局限期软组织肉瘤(STS)的疗效并分析其预后因子,重点探讨术后放疗在STS治疗中的作用。方法 回顾分析2000—2010年7月在复旦大学附属肿瘤医院接受保留器官手术的203例STS患者,76例(37.4%)接受辅助放疗,采用前后对穿野放疗技术,剂量45~70 Gy。采用 Kaplan-Meier法计算生存率并Logrank法检验,Cox模型多因素分析。结果 随访率94.7%,5年OS、LFFS、DMFS率分别为69.1%、69.3%、68.0%。多因素分析显示病理亚型、大小、切缘状况和是否接受放疗是影响OS因素,其中放疗显著降低STS患者LR风险(HR=0.327,95%CI为0.177~0.605,P=0.000),放疗显著提高OS (HR=0.489,95%CI为0.266~0.897,P=0.021)。结论 术后放疗不仅可提高STS的LC还可改善患者OS,其作用值得进一步研究。
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作者相关文章
赵如平
俞晓立
章真
冯炎
杨昭志
王坚
郭小毛
关键词 软组织肉瘤/放射疗法放射疗法术后预后    
AbstractObjective To investigate the treatment outcome of patients with localized soft tissue sarcoma (STS) and related prognostic factors, with a focus of the role of postoperative radiotherapy in the treatment of STS. Methods A retrospective analysis was performed for the clinical data of 203 STS patients who underwent organ preservation surgery in Fudan University Shanghai Cancer Center from July 2000 to July 2010. Of all the patients, 76(37.4%) received adjuvant radiotherapy, which was delivered via anterior-posterior parallel opposed fields at a dose of 45-70 Gy. The Kaplan-Meier method was used to calculate survival rates, the log-rank test was used for survival difference analysis, and the Cox proportional hazards model was used for multivariate analysis. Results The follow-up rate was 100%. The 5-year overall survival (OS) rate, local failure-free survival rate, and distant metastasis-free survival rate were 69.1%, 69.2%, and 68.0%, respectively. The multivariate analysis showed that pathological subtype, tumor size, resection margin status, and postoperative radiotherapy were influencing factors for OS. Among these factors, postoperative radiotherapy was associated with a significantly reduced risk of local recurrence in STS patients (HR=0.327, 95%CI 0.177-0.605, P=0.000) and a significantly increased OS rate (HR=0.489, 95%CI 0.266-0.897, P=0.021). Conclusions Postoperative radiotherapy can reduce local recurrence and improve OS in patients with localized STS, and further studies are needed to clarify its role.
Key wordsSoft tissue sarcoma/radiotherapy    Radiotherapy    postoperative    Prognosis   
收稿日期: 2015-11-09     
通讯作者: 郭小毛,Email:guoxm1800@163.com   
引用本文:   
赵如平,俞晓立,章真等. 术后辅助放疗对局限期软组织肉瘤疗效影响[J]. 中华放射肿瘤学杂志, 2016, 25(9): 934-938.
Zhao Ruping,Yu Xiaoli,Zhang Zhen et al. Effect of postoperative adjuvant radiotherapy on treatment outcome of patients with localized soft tissue sarcoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 934-938.
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