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放射性脑坏死的新认识与防治
王孝深,胡超苏
200032 上海,复旦大学上海医学院肿瘤学系复旦大学附属肿瘤医院放疗科
Research advances in prevention and treatment of cerebral radiation necrosis
Wang Xiaoshen,Hu Chaosu
Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China
Abstract：Cerebral radiation necrosis (CRN) is a serious complication of radiotherapy for intracranial tumors and skull base tumors. Since there lacked effective therapeutic methods in the past, CRN was once considered to be progressive and irreversible. With the development of histopathology and neuroimaging, the development and progression of CRN is gradually clarified, and new therapeutic methods have been developed. In recent years, the scholars at home and abroad have tried to use bevacizumab (a humanized monoclonal antibody targeting vascular endothelial growth factor), nerve growth factor, and ganglioside in the treatment of CRN and have achieved definite therapeutic effects. In some patients, cerebral necrosis was even repaired and reversed. This article reviews the incidence, pathophysiology, treatment, and prognosis of CRN.
Wang Xiaoshen,Hu Chaosu. Research advances in prevention and treatment of cerebral radiation necrosis[J]. Chinese Journal of Radiation Oncology, 2016, 25(9): 911-916.
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