Research advances in postoperative radiotherapy for esophageal squamous cell carcinoma
Luo Yijun,Li Minghuan,Zhu Yingming,Yu Jinming
School of Medicine and Life Sciences,Shandong Academy of Medical Sciences,University of Jinan,Ji’nan 250022,China (Luo YJ);Department of Radiotherapy,Shandong Cancer Hospital,Ji’nan 250117,China (Luo YJ,Li MH,Zhu YM,Yu JM)
Abstract：Surgery remains an important therapeutic method for localized esophageal cancer, but the 5-year survival rate of patients undergoing surgical resection alone is only 20%-25%. Early studies show that postoperative radiotherapy reduced regional recurrence rate, but did not increase the survival rate. Most recent studies show that stage Ⅲ or lymph node-positive patients can obtain survival benefit from postoperative radiotherapy, and patients in pT2-3N0M0 stage may also benefit from postoperative radiotherapy. The recommended radiotherapy target volumes include bilateral supraclavicular areas, superior mediastinum, subcarinal area, and tumor bed. It is recommended in most studies that regional lymph nodes in the upper abdomen should be included in patients with lower-segment lesions. The locally advanced patients may benefit more from postoperative radiotherapy combined with chemotherapy. The significance of postoperative radiotherapy for esophageal squamous cell carcinoma, target volume design, and combined chemotherapy need individualized consideration and more clinical evidence.
Luo Yijun,Li Minghuan,Zhu Yingming et al. Research advances in postoperative radiotherapy for esophageal squamous cell carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(8): 891-894.
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2016, Vol. 25 
