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聚腺苷二磷酸核糖聚合酶抑制剂联合放疗研究进展
罗婧,赵路军,刘宁波,王平
300060 天津,国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津医科大学肿瘤医院放疗科
Research advances in poly (ADP-ribose) polymerase inhibitors in combination with radiotherapy
Luo Jing,Zhao Lujun,Liu Ningbo,Wang Ping
Department of Radiation Oncology,Tumor Hospital of Medical Universityof Tianjin,Tianjin Key Laboratory of Tumor Prevention and Treatment,National Cancer Clinical Research Center,Tianjin 300060,China
Abstract：As a DNA damage sensor, poly (ADP-ribose) polymerase (PARP) is involved in a wide variety of cellular activities, such as DNA damage repair. PARP inhibitors regulate a series of cellular activities by inhibiting PARP function, which have become a focus of current research. Recently, several in vivo and in vitro studies showed that PARP inhibitors combined with radiotherapy effectively enhanced the efficacy of radiotherapy. This paper reviews the research advances in the mechanisms of action of PARP inhibitors and their combination with radiotherapy.
Luo Jing,Zhao Lujun,Liu Ningbo et al. Research advances in poly (ADP-ribose) polymerase inhibitors in combination with radiotherapy[J]. Chinese Journal of Radiation Oncology, 2016, 25(7): 782-786.
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2016, Vol. 25 
