Abstract：Objective To explore the effects of different courses of electro-acupuncture at Baihui, Fengfu, and Shenshu of both sides on the behavior of mice exposed to radiation. Methods Fifty C57BL/6J mice 30 days old were randomly and equally divided into control group, model group (exposure to radiation of 8 Gy), electro-acupuncture group 1(1 week of treatment), electro-acupuncture group 2(2 weeks of treatment), and electro-acupuncture group 3(3 weeks of treatment). The mouse model of radiation-induced brain injury was established by exposure to radiation of 8 Gy and treated with electro-acupuncture. The open field test and Morris water maze test were used to evaluate the cognitive function and spatial learning and memory, respectively. Group t-test difference. Results In the open field test, the model group had significantly fewer vertical or horizontal movements than the control group (P=0.032,0.029,0.028), while the electro-acupuncture groups 2 and 3 had significantly more vertical or horizontal movements than the model group (P=0.001,0.017,0.000). In the Morris water maze test, compared with the control group, the model group had significantly longer latency, a significantly lower frequency of entry into the goal box, and significantly shortened residence time, indicating substantially worse performance of spatial learning and memory (P=0.023,0.001,0.001).Compared with the model group, the electro-acupuncture groups 2 and 3 had significantly shortened latency, a significantly higher frequency of entry into the goal box, andsignificantly longer residence time (P=0.046,0.017,0.049,0.007,0.031,0.009). Conclusions Different courses of electro-acupuncture treatment at Baihui, Fengfu, and Shenshu of both sides can substantially improve the cognitive function and spatial learning and memory in mice exposed to radiation. Particularly, 2 and 3 weeks of electro-acupuncture treatment give the best outcomes.
Wu Xin,Zheng Wanjun,Li Lin et al. Experimental study on different courses of electro-acupuncture treatment on behavior of model mice with radiographic exposure[J]. Chinese Journal of Radiation Oncology, 2016, 25(6): 634-637.
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2016, Vol. 25 
