Department of Radiotherapy, Peking University Cancer Hospital& Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing),Beijing 100142,China (Zhang YB,Hu QQ,Yue HZH,Wu H);Department of Therapeutic Radiology, Yale University, New Haven CT 06510,USA (Deng J)
Abstract： Objective To investigate the dose distribution and radiation risk of Varian thoracic cone beam computed tomography (CBCT) with default parameters with reference to Monte Carlo simulation and International Commission on Radiological Protection (ICRP) report 110. Methods EGSnrc/BEAMnrc code was used to simulate the material, thickness, and geometry of the kV CBCT source (kVS) to establish the kVS model. A benchmarked MCSIM code was applied to calculate the dose distribution in the ICRP phantom after the scan with the standard thoracic parameters (110 kV, 20 mA, and 262 mAs), and the conversion coefficient of absolute dose was obtained in a spherical phantom following the TG-61 protocol. The results of Monte Carlo simulation were validated by PDD and Profile in a water phantom and the measurement of the absolute dose in the computed tomography dose index (CTDI) phantom and Alderson phantom. The models including BEIR VⅡ were used to evaluate the radiation risks. Results With reference to the criterion of 3%/1 mm, the uncertainties of PDD and Profile were less than 2%. The difference between the measured and calculated values was<2.9% in the CTDI phantom and ≤0.05 cGy in the Alderson phantom. In the ICRP110 phantom, the doses to the left lung, right lung, left breast, right breast, heart, thyroid, trachea, cancellous bone, and cortical bone were 1.28, 1.39, 1.74, 1.80, 1.46, 0.48, 0.88, 0.85, and 1.84 cGy, respectively. The relative risks of ischemic heart disease, breast cancer, lung cancer, thyroid cancer, and tracheal cancer in a standard scan were 1.001, 1.009, 1.019, 1.000, and 1.008, respectively. Conclusions The accumulated dose and long-term risks of CBCT during image-guided thoracic radiotherapy cannot be neglected and should be effectively controlled.
Zhang Yibao,Deng Jun,Hu Qiaoqiao et al. Imaging dose and risk of Varian thoracic cone beam CT to the ICRP computational reference phantom[J]. Chinese Journal of Radiation Oncology, 2016, 25(3): 275-278.
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