NSCLC-SBRT中4D-CBCT图像配准方式研究

doi:10.3760/cma.j.issn.1004-4221.2016.01.018

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摘要目的探讨在4D-CBCT扫描后,人工图像配准与灰度T+R图像配准在NSCLC (NSCLC) SBRT中的临床应用,得到在NSCLC-SBRT疗程中最适合的配准方式。方法 10例接受SBRT的NSCLC患者,在分次4D-CBCT扫描后,对扫描图像与定位CT图像分别进行人工与灰度T+R配准。在患者分次治疗过程中,对配准图像分别计算最大互信息、Haunsdorff距离、平均对称距离,并行配对t检验差异。结果第1~3次SBRT时,灰度T+R配准较人工配准的最大互信息平均提高8.8%(P=0.003,0.000,0.008),Haunsdorff距离平均减少21.1%(P=0.000,0.000,0.000),平均对称距离平均较少13.4%(P=0.000,0.002,0.018);第6~8次SBRT时,人工配准较灰度T+R配准的最大互信息平均提高19.3%(P=0.014,0.000,0.000),Haunsdorff距离平均减少17.6%(P=0.000,0.000,0.000),平均对称距离平均较少19.6%(P=0.001,0.000,0.000)。结论在NSCLC患者治疗前期,4D-CBCT后应用灰度T+R进行图像配准较为合理,治疗后期应用人工配准较为合理。

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	王佳浩
	李夏东
	夏冰
	邓清华
	徐莉霞
	任垚
	赖建军
	唐荣军

关键词 ：体层摄影术, X线计算机, 锥形束, 四维, 图像配准, 人工, 图像配准, 灰度T+R, 最大互信息, Haunsdorff距离, 平均对称距离

Abstract：Objective To investigate the artificial and gray T+R 4D-CBCT image registration for non-small cell lung cancer (NSCLC) with SBRT. Methods 2D SBRT 10 patients with NSCLC,their 4D-CBCT scan images and reference CT images were registered by the methods of artificial and gray T+R registration. The maximum mutual information (MI),Haunsdorff distance and average symmetry distance (ASD) were calculated and were analyzed by paired-t test. Results In 1-3 fraction SBRT,the maximum MI for Gray T+R registration was averaged improved 8.8%(P=0.003,0.000,0.008),Haunsdorff distance and ASD were averaged reduced 21.1%(P=0.000,0.000,0.000) and 13.4%(P=0.000,0.002,0.018) respectively,and they all had the statistical significance compared with artificial registration in the early period of treatment;in 6-8 fraction SBRT,compared with gray T+R registration the maximum MI for artificial registration was averaged improved 19.3%(P=0.014,0.000,0.000),Haunsdorff distance and ASD were averaged reduced 17.6%(P=0.000,0.000,0.000) and 19.6%(P=0.001,0.000,0.000) respectively,and they also had the statistical significance. Conclusions Gray T+R image registration was reasonable in early period of treatment and artificial image registration was available in later period of treatment.

Key words： Tomography,X-ray computed,cone beam,four-dimensional Image registration,artificial Image registration,gray T+R Maximum mutual information Haunsdorff distance Average symmetry distance

收稿日期: 2014-05-07

通讯作者: 李夏东,Email:hehe8812@126.com

引用本文:

王佳浩,李夏东,夏冰等. NSCLC-SBRT中4D-CBCT图像配准方式研究[J]. 中华放射肿瘤学杂志, 2016, 25(1): 71-75.

Wang Jiahao,Li Xiadong,Xia Bing et al. The application research about registration methods of 4D-CBCT in non-small cell lung cancer with SBRT[J]. Chinese Journal of Radiation Oncology, 2016, 25(1): 71-75.

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