Abstract：Objective To investigate the therapeutic effect of postoperative intensity-modulated radiotherapy (IMRT) in patients with soft tissue sarcomas (STSs) of the extremities and trunk wall. Methods The clinical data of 80 patients with STSs of the extremities and trunk wall who were admitted and treated from 2005 to 2011 were analyzed retrospectively. All the patients received postoperative IMRT after conservation surgery, among whom 51 patients had primary lesions in the extremities and 29 had primary lesions in the trunk wall. Seventy-one patients achieved negative resection margin. The median dose of IMRT was 64 Gy. The Kaplan-Meier method was applied to calculate survival rates, the log-rank test was used for survival difference analysis, and the Cox proportional hazards model was applied for multivariate prognostic analysis. Results The 5-year sample size was 43. The 5-year local control (LC) rate, distant metastasis-free survival rate, progression-free survival rate, and 5-year overall survival (OS) rate were 88%, 75%, 73%, and 84%, respectively. The patients with negative resection margin had a significantly higher 5-year LC rate than those with positive resection margin (90% vs. 65%, P=0.023). The patients with primary tumor ≤5 cm had a significantly higher 5-year OS rate than those with primary tumor>5 cm (95% vs. 69%, P=0.041). Multivariate analysis revealed that positive resection margin was an independent risk factor for LC rate (HR=5.33, 95%CI 1.19-23.86, P=0.029). During follow-up, the overall incidence rates of edema and joint stiffness were 18% and 10%, respectively. Conclusions Patients with STSs of the extremities and trunk wall can achieve a high LC rate after postoperative IMRT, with low incidence rates of long-term adverse events.
Wang Jianyang,Wang Shulian,Song Yongwen et al. Therapeutic effect of postoperative intensity-modulated radiotherapy in patients with soft tissue sarcomas of the extremities and trunk wall[J]. Chinese Journal of Radiation Oncology, 2016, 25(1): 46-49.
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