Department of Radiation Oncology,Shandong Cancer Hospital and Institute,Ji’nan 250117, China (Dong W);Department of Radiation Oncology,Peking University School of Oncology, Beijing Cancer Hospital＆Institute,Beijing 100142, China (Sun Y,Hu QQ,Zheng BM,Xiao SW,Zhu GY)
Abstract：Objective To investigate the role of large-diameter magnetic resonance imaging (MRI)simulation in target volume delineation in radiotherapy for nasopharyngeal carcinoma (NPC). MethodsEighteen patients with NPC underwent computed tomography (CT) simulation and MRI simulation scans and localization in the same body position, with SOMATOM Sensation Open 40-row 82-cm large-diameter CT simulator and Siemens 3T MRI MAGNETOM Skyra 70-cm large-diameter simulator, respectively. The gross tumor volume (GTV) and parotid glands were delineated on all images according to the ICRU Report 50/62, and MRI was applied to observe the changes in GTV and parotid volume during radiotherapy. Paired t-test was applied to analyze the differences between GTVCT and GTVMRI and between GTVnx-CT and GTVnx-MRI. Results GTVMRI decreased significantly compared with GTVCT, and the average volume decreased from (213.64±84.59) cm3 to (199.68±84.69) cm3(P=0.006). As for the volume of primary lesions in the nasopharynx, GTVnx-MRI was significantly smaller than GTVnx-CT, and the volume decreased from (95.75±24.76) cm3 to (88.12±26.25) cm3(P=0.001);as for the volume of cervical lymph nodes, GTVnd-MRI was significantly smaller than GTVnd-CT, and the volume decreased from (117.89±72.69) cm3 to (111.56±70.69) cm3(P=0.018). The targets delineated by CT and MRI did not overlap completely, with major differences in skull base bone and cervical soft tissue. The volume of both parotid glands delineated on MRI image was higher than that delineated on CT image, with a major difference in the deep lobe. MRI showed that GTV was reduced by 82.64±16.87% during radiotherapy, and the volumes of the left and right parotid glands were reduced by (32.7±23.95)% and (34.7±21.72)%, respectively. Conclusions The delineation of target volume based on MRI simulation is more accurate than that based on CT simulation and can achieve a smaller volume range, which helps to guide target volume delineation in radiotherapy for NPC accurately.
Dong Wei,Sun Yan,Hu Qiaoqiao et al. Role of large-diameter MRI simulation in target volume delineation in radiotherapy for nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(1): 4-8.
2016, Vol. 25 
