Comparison of planning parameter selection for volumetric modulated arc therapy of nasopharyngeal carcinoma in two different treatment planning systems
Ma Yan*,Zheng Jian,Deng Xiaowu,Huang Shaomin,Chen Li
*Department of Radiotherapy,Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou 510655,China
Abstract：Objective To investigate the impact of planning parameter settings on plan quality and delivery efficiency of VMAT for nasopharyngeal carcinoma with two treatment planning systems (TPS),as references for clinic plan optimization. Methods 25 patients with nasopharyngeal carcinoma were selected and planned for SIB-VMAT treatment. The same planning aims were used in the two kinds of TPS (TPS-1 and TPS-2).Multiple planning parameters were set for plan optimization. Dose distribution to the target volumes and organs at risk,monitor unit (MU) and delivery time were compared. Paired t-test or one-way ANOVA was used for the data which was in accordance to normal distribution;otherwise,nonparametric Wilcoxon signed rank test or nonparametric Friedman test was used. Results More segments lead to better plan quality and less MU but longer delivery time (Minor impact was observed when segment number was larger than 120) in TPS-1,while it had little impact on both plan quality and delivery efficiency in TPS-2.Comparing to single-arc plans,dual-arc VMAT achieved no significant benefit in plan quality but had more MU and longer delivery time in TPS-1(P=0.000).However,dual-arc VMAT plans had better dose distribution in TPS-2,decreased the maximum and mean dose for spinal cord in 3.9% and 13.7% respectively (P=0.000,0.000).Changing the settings of maximum or minimum dose rate did not affect the plan quality in both of the tested TPSs. Increasing the maximum or minimum dose rate reduced the delivery time but the latter increased the number of MU (P=0.000,0.000). Conclusions VMAT plan quality and delivery efficiency is affected significantly and differently by planning parameter settings for two TPSs. Trial test should be conducted for different TPS to determine the optimal parameter settings.
Ma Yan*,Zheng Jian,Deng Xiaowu et al. Comparison of planning parameter selection for volumetric modulated arc therapy of nasopharyngeal carcinoma in two different treatment planning systems[J]. Chinese Journal of Radiation Oncology, 2015, 24(5): 564-568.
2015, Vol. 24 
