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中华放射肿瘤学杂志
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中华放射肿瘤学杂志  2015, Vol. 24 Issue (4): 431-433    DOI: 10.3760/cma.j.issn.1004-4221.2015.04.019
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胶质母细胞瘤同期推量IMRT安全性分析
王政, 姜炜, 庞青松, 王平
300060 天津,国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室 天津医科大学肿瘤医院放疗科(王政、庞青松、王平);天津市环湖医院放疗科(姜炜)
Safety analysis of Intensity-modulated radiation therapy of glioblastoma with simultaneous integrated boost technique
Wang Zheng*,Jiang Wei,Pang Qingsong,Wang Ping
*Department of Radiation Oncology,Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Laboratory of Cancer Prevention and Therapy,National Clinical Research Center for Cancer,Tianjin 300060,China
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摘要 目的 评价同期推量IMRT技术治疗胶质母细胞瘤的安全性。方法 回顾分析天津市环湖医院2013—2014年接受同期推量IMRT的恶性胶质瘤患者共 46例,观察疗后生存获益及神经不良反应。Kaplan-Meier法生存分析,Cox模型多因素预后分析。结果 全组患者均顺利完成治疗。随访率100%,1年OS率73%,1年PFS 为39%。多因素分析提示联合替莫唑胺同期放化疗是影响生存因素(P=0.016)。16例出现肿瘤进展,其中局部复发 9例、远处播散 7例。结论 同期推量IMRT对胶质母细胞瘤患者的治疗安全有效,但鉴于例数偏少且随访时间较短值得进一步探索。
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王政
姜炜
庞青松
王平
关键词 胶质母细胞瘤/调强放射疗法调强放射疗法同期推量安全性    
Abstract:Objective To investigate clinical efficacy of simultaneous integrate boost for glioblastoma with intensity-modulated radiotherapy (SIB-IMRT). Methods A total of 46 patients with glioblastoma who underwents SIB-IMRT from January 2013 to August 2014,were retrospectively analyzed. Toxicity after completion of SIB-IMRT were assessed. Kaplan-Meier method was used to analyze survival and progression-free survival. Multivariate analyses were performed to determine significant prognostic factors. Results There was no patients delayed by more than grade 3 radiation toxicity. The median overall survival and 1-year survival rates was 69 weeks and 73%,respectively. The progression free survival and 1-year progression-free survival rate were 43 weeks and 39%,respectively. The pattern of failure was identical (9 Local, 7 distant and 0 marginal recurrence). Multivariate analyses show that temozolomide concurrent chemoradiotherapy were independent factors correlated to prognosis. Conclusions The preliminary results demonstrate that SIB-IMRT for glioblastoma appear to be effective and safe. With the limted number of patients in this group,SIB-IMRT could be used for treating glioblastoma with caution,which deserves further study.
Key wordsGlioblastoma/intensity modulated radiotherapy    Intensity modulated radiotherapy,simultaneous integrate boost    Safety analysis   
收稿日期: 2015-02-27     
通讯作者: 王平,Emailtjdoctorwang@163.com   
引用本文:   
王政,姜炜,庞青松等. 胶质母细胞瘤同期推量IMRT安全性分析[J]. 中华放射肿瘤学杂志, 2015, 24(4): 431-433.
Wang Zheng*,Jiang Wei,Pang Qingsong et al. Safety analysis of Intensity-modulated radiation therapy of glioblastoma with simultaneous integrated boost technique[J]. Chinese Journal of Radiation Oncology, 2015, 24(4): 431-433.
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