[1] Mehta V. Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function,prediction,and prevention[J]. Int J Radiat Oncol Biol Phys,2005,63(1):5-24. [2] Kong FM,Zhao J,Wang J,et al. Radiation dose effect in locally advanced non-small cell lung cancer[J]. J Thorac Dis,2014,6(4):336-347.DOI:10.3978/j.issn.2072-1439.2014.01.23. [3] Vogelius IR,Bentzen SM. A literature-based meta-analysis of clinical risk factors for development of radiation induced pneumonitis[J]. Acta Oncol,2012,51(8):975-983. DOI:10.3109/0284186X.2012.718093. [4] Provatopoulou X,Athanasiou E,Gounaris A. Predictive markers of radiation pneumonitis[J]. Anticancer Res,2008,28(4C):2421-2432. [5] 陆春叶,夏家辉.人类单核苷酸多态性及其应用 [J].国外医学遗传学分册,2001(01):21-24. [6] The International HapMap Consortium.The international HapMap project[J].Nature,2003,426(6968):789-796. [7] Bakkenist CJ,Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation[J]. Nature,2003,421(6922):499-506. [8] Morgan JL,Holcomb TM,Morrissey RW. Radiation reaction in ataxia telangiectasia[J]. Am J Dis Child,1968,116(5):557-558. [9] Zhang L,Yang M,Bi N,et al. ATM polymorphisms are associated with risk of radiation-induced pneumonitis[J]. Int J Radiat Oncol Biol Phys,2010,77(5):1360-1368.DOI:10.1016/j.ijrobp.2009.07.1675. [10] Xiong H,Liao Z,Liu Z,et al. ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy[J]. Int J Radiat Oncol Biol Phys,2013,85(4):1066-1073.DOI:10.1016/j.ijrobp.2012.09.024. [11] Yin M,Liao Z,Liu Z,et al. Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy[J]. Int J Radiat Oncol Biol Phys,2011,81(3):e67-e73.DOI:10.1016/j. ijrobp.2010.11.079. [12] Li H,Liu G,Xia L,et al. A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy[J]. Br J Radiol,2014,87(1040):20140093. DOI:10.1259/bjr.20140093. [13] Yin M,Liao Z,Huang YJ,et al. Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy[J/OL].PLoS One,2011,6(5):e20055[2014-10-25].http:// www.ncbi.nlm.nih.gov/pmc/articles/PMC3102071/.DOI:10.1371/journal.pone.0020055. [14] Ohnishi T,Mori E,Takahashi A. DNA double-strand breaks: their production,recognition,and repair in eukaryotes[J]. Mutat Res,2009,669(1-2):8-12.DOI:10.1016/j.mrfmmm.200 9.06.010. [15] Yin M,Liao Z,Liu Z,et al. Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy[J]. Cancer,2012,118(2): 528-535.DOI:10.1002/cncr.26214. [16] 李晋涛,刘昕,吴玉章.p53基因与DNA修复 [J]. 国外医学分子生物学分册,2001(03):151-153. [17] Yang M,Zhang L,Bi N,et al. Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy[J]. Int J Radiat Oncol Biol Phys,2011,79(5):1402-1407. DOI:10.1016/j.ijrobp.2009.12.042. [18] Mak RH,Alexander BM,Asomaning K,et al. A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase(MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy[J]. Cancer,2012,118(14):3654-3665. DOI:10.1002/cncr.26667. [19] Weisberg I,Tran P,Christensen B,et al. A second genetic polymorphism in methylenetetrahydrofolate reductase(MTHFR) associated with decreased enzyme activity[J]. Mol Genet Metab,1998,64(3):169-172. [20] Batra V,Kesavan V,Mishra KP. Modulation of enzymes involved in folate dependent one-carbon metabolism by gamma-radiation stress in mice[J]. J Radiat Res,2004,45(4): 527-533. [21] Barnett GC,West CM,Dunning AM,et al. Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype[J]. Nat Rev Cancer,2009,9(2):134-142. DOI:10.1038/nrc2587. [22] Barthelemy-Brichant N,Bosquee L,Cataldo D,et al. Increased IL-6 and TGF-beta1 concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy[J]. Int J Radiat Oncol Biol Phys,2004,58(3):758-767. [23] Anscher MS,Garst J,Marks LB,et al. Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury[J]. Int J Radiat Oncol Biol Phys,2006,66(2):477-482. [24] Liu Y,Xia T,Zhang W,et al. Variations of circulating endothelial progenitor cells and transforming growth factor-beta-1(TGF-beta1) during thoracic radiotherapy are predictive for radiation pneumonitis[J/OL]. Radiat Oncol,2013,8:189[2014-10-25].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766170/.DOI:10.1186/1748-717X-8-189. [25] Yuan X,Liao Z,Liu Z,et al. Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy[J]. J Clin Oncol,2009,27(20):3370-3378. DOI:10.1200/JCO.2008.20.6763. [26] Niu X,Li H,Chen Z,et al. A study of ethnic differences in TGFbeta1 gene polymorphisms and effects on the risk of radiation pneumonitis in non-small-cell lung cancer[J]. J Thorac Oncol,2012,7(11):1668-1675. DOI:10.1097/JT O.0b01 3e318 267cf5b. [27] Wang L,Bi N. TGF-beta1 gene polymorphisms for anticipating radiation-induced pneumonitis in non-small-cell lung cancer: different ethnic association[J]. J Clin Oncol,2010,28(30):e621-e622. DOI:10.1200/JCO. 2010.31.0458. [28] Voets AM,Oberije C,Struijk RB,et al. No association between TGF-beta1 polymorphisms and radiation-induced lung toxicity in a European cohort of lung cancer patients[J]. Radiother Oncol,2012,105(3):296-298.DOI:10.1016/j.radon c. 2012.09.016. [29] Hildebrandt MA,Komaki R,Liao Z,et al. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer[J/OL].PLoS One,2010,5(8): e12402[2014-10-25].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928273/.DOI:10.1371/journal.pone.0012402. [30] 时鹏,王明明,孙靖中,等.HSPb1真核表达载体的构建及其在乳腺癌细胞中表达的研究 [J].中国现代普通外科进展,2007,10(6):467-470. [31] Arrigo AP. Hsp27: novel regulator of intracellular redox state[J]. IUBMB Life,2001,52(6):303-307. [32] Cheng EH,Wei MC,Weiler S,et al. BCL-2,BCL-X(L) sequester BH3 domain-only molecules preventing BAX-and BAK-mediated mitochondrial apoptosis[J]. Mol Cell,2001,8(3):705-711. [33] Pinthus JH,Bryskin I,Trachtenberg J,et al. Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapy[J]. Neoplasia,2007,9(1):68-80. [34] Pang Q,Wei Q,Xu T,et al. Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer[J]. Int J Radiat Oncol Biol Phys,2013,85(5): 1332-1339. DOI:10.1016/j.ijrobp.2012.10.011. [35] Marumo T,Schini-Kerth VB,Busse R. Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells[J]. Diabetes,1999,48(5):1131-1137. [36] Kim I,Moon SO,Kim SH,et al. Vascular endothelial growth factor expression of intercellular adhesion molecule 1(ICAM-1),vascular cell adhesion molecule 1(VCAM-1),and E-selectin through nuclear factor-kappa B activation in endothelial cells[J]. J Biol Chem,2001,276(10):7614-7620. [37] Yin M,Liao Z,Yuan X,et al. Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy[J]. Cancer Sci,2012,103(5):945-950.DOI:10.1111/j.1349-7006.2012.02229.x.