Abstract：Objective To study a novel method for the high-dose-rate brachytherapy (HDR) CT image to the intensity modulated radiation therapy (IMRT) CT image deformable image registration and dose accumulation. Methods The applicator in the HDR CT image is first segmented and removed, then a deflation step is performed on the applicator-free HDR CT image by solving the Navier-Stokes equation. Demons algorithm is utilized to register the deflated HDR CT image to the IMRT CT image, along with the HDR dose. The deformed HDR dose is then added on the IMRT dose and yield the final accumulated dose. Results The HDR CT image and IMRT CT image, as well as the corresponding dose distribution, from the cervical cancer patients are used for evaluation of the proposed algorithm, the results show that the proposed method can effectively get rid of the influence of the applicator and produce an accurate accumulated dose. Conclusions Dose accumulation and supervision is an important step in adaptive radiotherapy for accurate dose delivery and treatment plan re-optimization. The proposed method in this study can effectively accumulate the HDR dose to the IMRT dose domain, and the accuracy is proved to be sufficient for clinical needs.
Zhen Xin,Chen Haibin,Xiao Yang et al. A study of deformable image registration of high-dose-rate brachytherapy CT image to intensity modulated radiation therapy CT image[J]. Chinese Journal of Radiation Oncology, 2015, 24(2): 209-211.
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2015, Vol. 24 
