Abstract：Objective To evaluate the dosimetry for the patients with breast cancer in post-mastectomy radiotherapy. Methods Thirty one patients from Nov 2012 to May 2013 with breast cancer were treated with mastectomy surgery followed by radiotherapy. They were planned using:1) improved tangential wedge-based fields IMRT (P1);2) 4 beam rotary inverse IMRT (P2);3) 5 beam-field IMRT (P3);and 4) Dual arc VMAT (P4). The PTV and OAR including the cardiac, left anterior descending artery (LAD), the right coronary artery (RCA), ipsilateral lung. The CI and HI of PTV and volumetric dose PRV-OAR were analyzed by single factor variance analysis or χ2 test methods. Results The CI and HI for P1-P4 with both sides were L:P=0.009,R:P=0.000. The NTCP_Heart with tumor in right side was:0.19%,4.76×10－3%,0,0(P=0.568),with tumor in the other side was:2.7%,1.1%,1.3%,0.86%(P=0.390). The NTCP_Lung_Sick for P1-P4 were left side:9.73%,7.52%,8.86%,10.73%(P=0.953);Right side:11.73%,8.65%,7.02%,11.25%(P=0.437). The TCP for P1-P4 with both sides were L:P=0.000,R:P=0.000). Conclusions There had no statistically difference of NTCP_Heart and NTCP_Lung_Sick in plans employed with heart faced (involved) beams or arc within our research group, while had statistically benefit to improve the CI of PTV and the dose homogeneity of target, 5 beam-field IMRT or VMAT plan could be choose as cardiac safe and efficient techniques for patients with breast cancer in post-mastectomy surgery.
Li Xiadong,Deng Qinghua,Ma Shenglin et al. Patients with breast cancer in post-mastectomy radiotherapy employed with heart faced radiation beam:dosimetric risk and benefits analysis[J]. Chinese Journal of Radiation Oncology, 2015, 24(1): 65-69.
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