[1] Tyldesley S,Boyd C,Schulze K,et al. Estimating the need for radiotherapy for lung cancer: an evidence-based,epidemiologic approach[J].Int J Radiat Oncol Biol Phys,2001,49(4):973-985. DOI: 10.1016/S0360-3016(00)01401-2. [2] Machtay M,Bae K,Movsas B,et al. Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group[J].Int J Radiat Oncol Biol Phys,2012,82(1):425-434. DOI: 10.1016/j.ijrobp.2010.09.004. [3] Kong F,Ten Haken R,Schipper M,et al. High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small cell lung cancer: long-term results of a radiation dose escalation study[J].Int J Radiat Oncol Biol Phys,2005,63(2):324-333. DOI: 10.1016/j.ijrobp.2005.02.010. [4] Kong FM,Ten Haken R,Eisbruch A,et al. Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis[J].Semin Oncol,2005,32(2 Suppl 3):42-54. DOI: 10.1053/j.seminoncol.2005.03.009. [5] Anscher MS,Kong FM,Marks LB,et al. Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis[J].Int J Radiat Oncol Biol Phys,1997,37(2):253-258.DOI: 10.1016/S0360-3016(96)00529-9. [6] Goto K,Kodama T,Sekine I,et al. Serum levels of KL-6 are useful biomarkers for severe radiation pneumonitis[J].Lung Cancer,2001,34(1):141-148. DOI: 10.1016/S0169-5002(01)00215-X. [7] Zhao L,Wang L,Ji W,et al. Elevation of plasma TGF-beta1 during radiation therapy predicts radiation-induced lung toxicity in patients with non-small cell lung cancer: a combined analysis from Beijing and Michigan[J].Int J Radiat Oncol Biol Phys,2009,74(5):1385-1390.DOI: 10.1016/j.ijrobp.2008.10.065. [8] Chen YY,Williams J,Ding I,et al. Radiation pneumonitis and early circulatory cytokine markers[J].Semin Radiat Oncol,2002,12(1 Suppl 1):26-33.DOI: 10.1053/srao.2002.31360. [9] Trotti A,Colevas A,Setser A,et al. CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment[J].Semin Radiat Oncol,2003,13(3):176-181.DOI: 10.1016/S1053-4296(03)00031-6. [10] Bradley J,Graham MV,Winter K,et al. Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small cell lung carcinoma[J].Int J Radiat Oncol Biol Phys,2005,61(2):318-328.DOI: 10.1016/j.ijrobp.2004.06.260. [11] Cox JD,Stetz J,Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group(RTOG) and the European Organization for Research and Treatment of Cancer(EORTC)[J].Int J Radiat Oncol Biol Phys,1995,31(5):1341-1346. DOI:10.1016/0360-3016(95)00060-C. [12] 徐慧敏,曹建忠,王静波,等.非小细胞肺癌放疗后有症状放射性肺损伤治疗及转归分析[J].中华放射肿瘤学杂志,2013,22(3):201-204.DOI: 10.3760/cma.j.issn.1004-4221.2013.03.008. [13] 徐慧敏,曹建忠,王静波,等.非小细胞肺癌放疗后有症状放射性肺损伤临床特点分析[J].中华放射肿瘤学杂志,2013,22(2):118-122.DOI: 10.3760/cma.j.issn.1004-4221.2013.02.009. [14] Cancer Therapy Evaluation Program[DB/OL][2014-06-20].http://ctep.cancer.gov/reporting/ctc.html. [15] Green S,Weiss GR. Southwest Oncology Group standard response criteria,endpoint definitions and toxicity criteria[J].Invest New Drugs,1992,10(4):239-253. DOI:10.1007/BF00944177. [16] Kong FM,Hayman JA,Griffith KA,et al. Final toxicity results of a radiation-dose escalation study in patients with non-small cell lung cancer(NSCLC): predictors for radiation pneumonitis and fibrosis[J].Int J Radiat Oncol Biol Phys,2006,65(4):1075-1086. DOI: 10.1016/j.ijrobp.2006.01.051. [17] Pavy JJ,Denekamp J,Letschert J,et al. EORTC Late Effects Working Group. Late effects toxicity scoring: the SOMA scale[J].Radiother Oncol,1995,35(1):11-15. DOI: 10.1016/0167-8140(95)97448-M. [18] Greos LS,Vichyanond P,Bloedow DC,et al. Methylprednisolone achieves greater concentrations in the lung than prednisolone. A pharmacokinetic analysis[J]. Am Rev Respir Dis,1991,144(3 Pt 1):586-592. DOI: 10.1164/ajrccm/144.3_Pt_1.586. [19] Sekine I,Sumi M,Ito Y,et al. Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients.Radiother Oncol,2006,80(1):93-97. DOI: 10.1016/j.radonc.2006.06.007. [20] Rodrigues G,Lock M,D′Souza D,et al. Prediction of radiation pneumonitis by dose-volume histogram parameters in lung cancer—a systematic review[J].Radiother Oncol,2004,71(2):127-138. DOI: 10.1016/j.radonc.2004.02.015. [21] Zhao L,Ji W,Ou G,et al. Risk factors for radiation-induced lung toxicity in patients with non-small cell lung cancer who received postoperative radiation therapy[J].Lung Cancer,2012,77(2):326-330. DOI: 10.1016/j.lungcan.2012.03.017. [22] 王谨,庄婷婷,何智纯,等.非小细胞肺癌同期放化疗后重度急性放射性肺炎的预测因素[J].中华放射肿瘤学杂志,2012,21(4):326-329.DOI: 10.3760/cma.j.issn.1004-4221.2012.04.011. [23] Wang J,Cao J,Yuan S,et al. Poor baseline pulmonary function may not increase the risk of radiation-induced lung toxicity[J].Int J Radiat Oncol Biol Phys,2013,85(3):798-804.DOI: 10.1016/j.ijrobp.2012.06.040. [24] Wang D,Sun J,Zhu J,et al. Functional dosimetric metrics for predicting radiation-induced lung injury in non-small cell lung cancer patients treated with chemoradiotherapy[J/OL].Radiat Oncol,2012,7:69[2014-06-20].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434088/.DOI:10.1186/1748-717X-7-69. [25] Fu XL,Huang H,Bentel G,et al. Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V-30 and transforming growth factor beta[J].Int J Radiat Oncol Biol Phys,2001,50(4):899-908. DOI:10.1016/S0360-3016(01)01524-3. [26] Yuan X,Liao Z,Liu Z,et al. Single nucleotide polymorphism at rs1982073:T869C of the TGF beta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy[J].J Clin Oncol,2009,27(20):3370-3378. DOI: 10.1200/JCO.2008.20.6763. [27] Wang L,Bi N. TGF-beta1 gene polymorphisms for anticipating radiation-induced pneumonitis in non-small-cell lung cancer: different ethnic association[J].J Clin Oncol,2010,28(30):621-622. DOI: 10.1200/JCO.2010.31.0458. [28] Zhang L,Yang M,Bi N,et al. ATM polymorphisms are associated with risk of radiation-induced pneumonitis[J].Int J Radiat Oncol Biol Phys,2010,77(5):1360-1368. DOI: 10.1016/j.ijrobp.2009.07.1675. [29] Xiong H,Liao Z,Liu Z,et al. ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy[J].Int J Radiat Oncol Biol Phys,2013,85(4):1066-1073. DOI: 10.1016/j.ijrobp.2012.09.024.
2015, Vol. 24 
