[1] Sulli G,Di Micco R,d′Adda di Fagana F. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer[J]. Nat Rev Cancer,2012,12:709-720. [2] Jeggo PA,Geuting V,Lbrich M. The role of homologous recombination in radiation-induced double-strand break repair[J]. Radiother Oncol,2011,101:7-12. [3] Fu D,Calvo JA,Samson LD. Balancing repair and tolerance of DNA damage caused by alkylating agents[J]. Nat Rev Cancer,2012,12:104-120. [4] Deans AJ,West SC. DNA interstrand crosslink repair and cancer[J]. Nat Rev Cancer,2011,11:467-480. [5] Bunting SF,Nussenzweig A. End-joining,translocations and cancer[J]. Nat Rev Cancer,2013,13:443-454. [6] Friedberg EC. A brief history of the DNA repair field[J]. Cell Res,2008,18:3-7. [7] Kelley MR. DNA repair in cancer therapy:molecular targets and clinical applications[M].London: Elsevier/Academic Press,2012:316. [8] Serrano MA,Li Z,Dangeti M,et al. DNA-PK,ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair[J]. Oncogene,2013,32:2452-2462. [9] Langerak P,Mejia-Ramirez E,Limbo O,et al. Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks[J/OL]. PLoS Genet,2011,7:1002271[2014-04-08].http://www.biomedsearch.com/nih/Release-Ku-MRN-from-DNA/21931565.html. [10] Kirshner M,Rathavs M,Nizan A,et al. Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair[J]. DNA Repair(Amst),2009,8:253-261. [11] Roy R,Chun J,Powell SN. BRCA1 and BRCA2: different roles in a common pathway of genome protection[J]. Nat Rev Cancer,2012,12:68-78. [12] Bonner WM,Redon CE,Dickey JS,et al. Gamma H2AX and cancer[J]. Nat Rev Cancer,2008,8:957-967. [13] Mah LJ,El-Osta A,Karagiannis TC. Gamma H2AX: a sensitive molecular marker of DNA damage and repair[J].Leukemia,2010,24:679-86. [14] Dobbs TA,Tainer JA,Lees-Miller SP. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation[J]. DNA Repair(Amst),2010,9:1307-1314. [15] Yannone SM,Khan IS,Zhou RZ,et al. Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase[J]. Nucleic Acids Res,2008,36:3354-3365. [16] Pawelczak KS,Bennett SM,Turchi JJ. Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ[J]. Antioxid Redox Signal,2011,14:2531-2543. [17] Mahaney BL,Meek K,Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining[J]. Biochem J,2009,417:639-650. [18] Weterings E,Chen DJ. DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?[J]. J Cell Biol,2007,179:183-186. [19] Hammel M,Yu Y,Mahaney BL,et al. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex[J]. J Biol Chem,2010,285:1414-1423. [20] Roberts SA,Strande N,Burkhalter MD,et al. Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends[J]. Nature,2010,464:1214-1217. [21] Hasty P. Is NHEJ a tumor suppressor or an aging suppressor?[J]. Cell Cycle,2008,7:1139-1145. [22] Weterings E,Verkaik NS,Keijzers G,et al. The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends[J]. Mol Cell Biol,2009,29:1134-1142. [23] Wang CY,Huang EY,Huang SC,et al. DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress[J/OL].Oncogene,2014,In press[Epub ahead of print][2014-04-08].http://www.ncbi.nlm.nih.gov/pubmed/?term=Wang+CY%2C+et+al.+DNA-PK%2FChk2+induces+centrosome+amplification+during+prolonged+replication+stress%5BJ%5D.+Oncogene%2C2014%2C. [24] Kysela B,Doherty AJ,Chovanec M,et al. Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule[J]. J Biol Chem,2003,278:22466-22474. [25] Vandersickel V,Mancini M,Slabbert J,et al. The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons[J/OL]. Radiat Oncol,2010,5:30[2014-04-08]. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877562/. [26] Peng Y,Woods RG,Beamish H,et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM[J]. Cancer Res,2005,65:1670-1677. [27] Bergs JW,Krawczyk PM,Borovski T,et al. Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining[J]. DNA Repair(Amst),2013,12:38-45. [28] Golding SE,Morgan RN,Adams BR,et al. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvⅢ enhances DNA double-strand break repair in human glioma cells[J]. Cancer Biol Ther,2009,8:730-738. [29] Bouwman P,Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance[J]. Nat Rev Cancer,2012,12:587-598. [30] Zimmermann M,de Lange T. 53BP1: pro choice in DNA repair[J]. Trends Cell Biol,2014,24:108-117. [31] Fradet-Turcotte A,Canny MD,Escribano-Díaz C,et al. 53BP1 is a reader of the DNA-damage-induced H2A Lys15 ubiquitin mark[J]. Nature,2013,499:50-54. [32] Ohta T,Sato K,Wu W. The BRCA1 ubiquitin ligase and homologous recombination repair[J]. FEBS Lett,2011,585:2836-2844. [33] Yin M,Liao Z,Liu Z,et al. Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy[J]. Cancer,2012,118:528-535. [34] Plummer R. Perspective on the pipeline of drugs being developed with modulation of DNA damage as a target[J]. Clin Cancer Res,2010,16:4527-4531. [35] Begg AC,Stewart FA,Vens C. Strategies to improve radiotherapy with targeted drugs[J]. Nat Rev Cancer,2011,11:239-253. [36] Gil del Alcazar CR,Hardebeck MC,Mukherjee B,et al. Inhibition of DNA double-strand break repair by the dual PI-3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma[J]. Clin Cancer Res,2014,20:1235-1248. [37] Kong D,Yamori T. Advances in development of phosphatidylinositol 3-kinase inhibitors[J]. Curr Med Chem,2009,16:2839-2854. [38] Li AY,Boo LM,Wang SY,et al. Suppression of nonhomologous end joining repair by overexpression of HMGA2[J]. Cancer Res,2009,69:5699-5706. [39] He F,Li L,Kim D,et al. Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions[J]. Cancer Res,2007,67:634-642. [40] Li GC,He F,Shao X,et al. Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivo[J]. Cancer Res,2003,63:3268-3274.
2014, Vol. 23 
