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中华放射肿瘤学杂志
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中华放射肿瘤学杂志  2014, Vol. 23 Issue (4): 322-325    DOI: 10.3760/cma.j.issn.1004-4221.2014.04.012
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每次在线图像引导下肺肿瘤SBRT临床疗效分析
高鸿, 李高峰, 钟秋子, 徐勇刚, 吴钦宏
100730,北京,卫生部北京医院放疗科
Clinical efficacy of daily online image-guided stereotactic body radiation therapy for lung cancer
Gao Hong,Li Gaofeng,Zhong Qiuzi,Xu Yonggang,Wu Qinhong
Department of Radiation Oncology, Beijing Hospital, Ministry of Health,Beijing 100730,China
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摘要 目的 分析每次在线CBCT图像引导下SBRT治疗原发和转移性肺癌的疗效及相关因素。方法 回顾2009—2013年间采用SBRT治疗的 36例肺肿瘤患者资料,包括原发肺癌 24例、转移性肺癌 12例。42个病灶中85.7%的BED10≥100 Gy。每次照射前采用CBCT扫描后采用在线自动和或手动配准使CBCT上肿瘤落入PTV、PGTV内,不设定摆位阈值,移床校正后进行照射。结果 全组1、2、3年样本数分别为36、29、26例。1、2、3年LC率分别为96%、89%、72%,CCS率分别为82%、74%、64%,OS率分别为78%、64%、53%。单因素分析未发现与LC率相关因素,多因素分析也未显示与OS率相关因素。单因素和多因素分析均显示只有肿瘤位置分类变量(中央型、周边型)与肿瘤特异生存相关,中央型与周边型病灶的CCS平均值、95%CI值分别为21.4、13.2~29.6个月与42.3、35.7~49.0个月(P=0.024)。结论 每次疗前在线图像引导SBRT在原发或转移性肺肿瘤均可取得满意LC率。
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作者相关文章
高鸿
李高峰
钟秋子
徐勇刚
吴钦宏
关键词 肺肿瘤/放射疗法放射疗法立体定向放射疗法图像引导预后    
Abstract:Objective To analyze the clinical efficacy of daily online cone-beam computed tomography (CBCT)-guided stereotactic body radiation therapy (SBRT) for primary and metastatic lung cancer and its related factors. Methods From May 2009 to May 2013, 36 patients with lung cancer were treated with SBRT, including 24 patients with primary lung cancer and 12 patients with metastatic lung cancer. The biologically effective dose at 10 Gy was ≥100 Gy in 85.7% of 42 lesions. Before each delivery, CBCT was acquired, and online automatic or manual registration was performed to make the tumors on CBCT within the planning target volume/primary gross tumor volume;the setup threshold was not set, and the couch was moved for correction. Results The 1-, 2-, and 3-year sample sizes were 36, 29, and 26, respectively. The 1-, 2-, and 3-year local control (LC) rates were 96%, 89%, and 72%, respectively. The 1-, 2-, and 3-year cancer-specific survival (CCS) rates were 82%, 74%, and 64%, respectively. The 1-, 2-, and 3-year overall survival (OS) rates were 78%, 64%, and 53%, respectively. Univariate analysis found no factors associated with LC. Multivariate analysis revealed no factors associated with OS. Both univariate and multivariate analyses showed that only tumor location (central type or peripheral type) was associated with CCS;the mean values (95% confidence intervals) of CCS in patients with central-type and peripheral-type lesions were 21.4 months (13.2—29.6 months) and 42.3 months (35.7—49.0 months), respectively (P=0.024). Conclusions Daily online image-guided SBRT for primary or metastatic lung cancer can lead to a satisfactory LC.
Key wordsLung neoplasms/radiotherapy    Radiotherapy, stereotactic    Radiotherapy, image-guided    Prognosis   
收稿日期: 2013-10-25     
引用本文:   
高鸿,李高峰,钟秋子等. 每次在线图像引导下肺肿瘤SBRT临床疗效分析[J]. 中华放射肿瘤学杂志, 2014, 23(4): 322-325.
Gao Hong,Li Gaofeng,Zhong Qiuzi et al. Clinical efficacy of daily online image-guided stereotactic body radiation therapy for lung cancer[J]. Chinese Journal of Radiation Oncology, 2014, 23(4): 322-325.
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http://journal12.magtechjournal.com/Jweb_fszlx/CN/10.3760/cma.j.issn.1004-4221.2014.04.012     或     http://journal12.magtechjournal.com/Jweb_fszlx/CN/Y2014/V23/I4/322
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