[an error occurred while processing this directive]|[an error occurred while processing this directive]
大分割与常规分割3DCRT原发性肝癌合并门脉癌栓的临床观察
芦东徽, 费振乐, 周俊平, 胡宗涛, 郝文胜
230031 合肥,解放军105医院肿瘤中心
Clinical efficacy of conventionally fractionated versus hypofractionated three-dimensional conformal radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis
Lu Donghui,Fei Zhenle,Zhou Junping, Hu Zongtao,Hao Wensheng
Department of Radiotherapy,PLA 105 Hospital,Hefei 230031,China
Abstract：Objective To observe the efficacy and adverse effects of conventionally fractionated (CF) versus hypofractionated (HF) three-dimensional conformal radiotherapy (3DCRT) for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis. Methods A retrospective analysis was performed on the clinical data of 65 patients with HCC suitable for 3DCRT from 2008 to 2012. These patients were randomly divided into HF group (n=32) and CF group (n=32). The HF group received 3DCRT at a total dose of 45—55 Gy (3—4 Gy/fraction, 3—5 fractions/week), while the CF group at a total dose of 40—56 Gy (2 Gy/fraction, 5 fractions/week). Results The follow-up rate was 100%. For the HF group and CF group, the short-term response rates were 72% vs. 55%(P=0.034), the 1-year local control rates were 72% vs. 55%(P=0.034), the 1-year overall survival rates were 59% vs. 45%(P=0.042), and the numbers of individuals with grade 1—2 acute gastrointestinal reactions, deterioration of liver function, and radiation hepatitis were 14 vs. 11, 8 vs. 8, and 1 vs. 0, respectively (P=0.237). Conclusions HF 3DCRT is superior to CF 3DCRT in the treatment of HCC.
Lu Donghui,Fei Zhenle,Zhou Junping et al. Clinical efficacy of conventionally fractionated versus hypofractionated three-dimensional conformal radiotherapy for hepatocellular carcinoma with portal vein tumor thrombosis[J]. Chinese Journal of Radiation Oncology, 2014, 23(2): 114-116.
2014, Vol. 23 
