Impact of FDG-PET/CT before intensity-modulated radiotherapy on treatment regimen in patients with esophageal cancer
Xie Yanting*, Zheng Rong, Wu Ning, Wang Lyuhua, Li Yexiong, Zhang Wenjie, Liang Ying, Liu Ying, Zhang Han, Li Xiaomeng, Fang Yan, Xiao Zefen, Liang Jun, Zhao Ping.
Department of Nuclear Medicine and PET-CT Center, Cancer Hospital, Chinese Academy of Medical Sciences,Peking Union Medical College, Beijing 100021, China
Abstract：Objective To investigate the impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) before intensity-modulated radiotherapy (IMRT) on treatment regimen in patients with newly diagnosed esophageal cancer. Methods A retrospective analysis was performed on 60 patients with esophageal cancer newly diagnosed by esophagoscopy, who underwent conventional imaging examination and IMRT. All patients underwent PET/CT before IMRT to evaluate whether the staging and treatment regimen would be changed. Results PET/CT provided additional information and led to changes in staging in 12 patients (2 patients with increased T stage, 6 patients with increased N stage, 2 patients with decreased N stage, and 2 patients with increased M stage). In addition, PET/CT changed management from radiotherapy to chemotherapy in 3 patients for detecting more distant metastases. The use of PET/CT led to changed target volumes in 20 of 57 patients:16 patients showed an increase in gross target volume or clinical target volume for more positive lymph nodes detected, and 4 patients exhibited target volume reduction for some positive lymph nodes excluded. Conclusions PET/CT has advantages in detecting positive local lymph nodes and distant metastases and helping improve the accuracy of staging in patients with esophageal cancer, which may lead to change in treatment regimen.
. Impact of FDG-PET/CT before intensity-modulated radiotherapy on treatment regimen in patients with esophageal cancer[J]. Chinese Journal of Radiation Oncology, 2014, 23(1): 31-33.
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2014, Vol. 23 
