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578例瘢痕疙瘩放疗疗效观察
孙玉亮，连欣，刘楠，张明杰，何蕾，刘博飞，张福泉
l00730北京协和医学院中国医学科学院北京协和医院放疗科
Electron-beam irradiation therapy for keloids:retrospective study of 578 cases
SUN Yu-liang, LIAN Xin, LIU Nan, ZHANG Ming-jie, HE Lei, LIU Bo-fei, ZHANG Fu-quan
Department of Radiotherapy, Peking Union Hospital,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College,Beijing 100730,China
Abstract：Objective To analyze the outcomes of radiotherapy for keloids by high energy electron beams and the factors influencing the treatment outcome. Methods From Jan 1998 to Jun 2012, 846 lesions in 578 patients received radiotherapy. The median age is 29 years old (range 5—80 years old). There are 841 lesions with postoperative radiotherapy and 39 lesions with skin-grafting. 656 lesions treated within 1 day after operations. The max diameter of 348 keloids are>5 cm. We used 6 MeV and 7 MeV electron-beam radiation therapy. The total dose ranging from 16—18 Gy/2f (interval 1 week). Treatment fields including entire keloid scars, and any suture/puncture holes with a 1 cm-margin around the lesion were used. The skin grafting patients need radiotherapy after the flap survived (about 10—15 days after the operation). The median follow-up period was 36 months (range 8—185 months). Results There are 736(87.0%) of 846 lesions with radiotherapy effective. Other 89(10.5%) lesions relapse in 4—33 months (median 12 months). 21 lesions were of no avail. The univariate analysis shows that keloids length, keloids location, skin-grafting, interval between operations and irradiations are the influencing factors of outcomes (P=0.007,0.000,0.000,0.001). The multivariate analysis shows that keloids location and skin-grafting remained statistically significant differences (P=0.001,0.001). Most of the recurrence cases are large and bent scars. Conclusions High-energy electron-beam radiotherapy for keloids can receive good outcomes. Treatment fields flat is very important for electron-beam radiotherapy.
SUN Yu-liang,LIAN Xin,LIU Nan et al. Electron-beam irradiation therapy for keloids:retrospective study of 578 cases[J]. Chinese Journal of Radiation Oncology, 2013, 22(6): 443-445.
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2013, Vol. 22 
