Abstract：Objective To investigate whether the T1-weighted dynamic contrast-enhanced perfusion magnetic resonance imaging (DCEPMRI) technique can help to delineate the clinical target volume of brain glioma patients. Methods The DCE T1-weighted images from 28 glioma patients were collected after Gd-DTPA was injected. After the acquired images were processed and analyzed using modified Tofts-Kermode′ two compartment analysis model and de-convolution method, the value and its pseudo mapping of quantitative parameter Ktrans related to microvascular permeability were obtained. The tumor size in the largest diameter slice measured both in routine enhanced MRI and Ktrans mapping of T1-weighted DCEPMRI were compared. Results The vascular permeability and tumor infiltration was lower in low grade glioma, the difference of the tumor size between T1-weighted DCEPMRI and routine enhanced MRI reached 0.2%－0.3% there was significant difference of tumor size between T1-weighted DCEPMRI and routine enhanced MRI (gradeⅠ and Ⅱ grade with 2.93 cm2∶2.46 cm2(t=6.90,P=0.000) and 4.18 cm2∶3.21 cm2(t=10.22,P=0.000)). While in high grade glioma, the vascular permeability and the tumor infiltration were higher, the difference of the tumor size between T1-weighted DCEPMRI and routine enhanced MRI reached 25%－26%(the size of grade Ⅲ and Ⅳ were 6.46 cm2 vs 5.48 cm2(t=10.83,P=0.000) and 8.26 cm2 vs 6.52 cm2(t=18.53,P=0.000)). Conclusions The pseudo mapping of quantitative parameter Ktrans related to microvascular permeability acquired by T1-weighted DCEPMRI reflect the infiltrating circumscription in glioma, T1-weighted DCEPMRI can provide more information in delineation the clinical target volume, and it can be used as a new method for tumor volume evaluation.
. The role of T1-weighted dynamic contrast-enhanced perfusion magnetic resonance imaging in gross target volume delineation of glioma patients[J]. Chinese Journal of Radiation Oncology, 2012, 21(4): 310-312.
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