[1] Barth RF,Coderre JA,Vicente GH,et al. Boron neutron capture therapy of cancer: current status and future prospects. Clin Cancer Res,2005,11:3987-4002. [2] Nakagawa Y,Pooh K,Kobayashi T,et al. Clinical review of the Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams. J Neurooncol,2003,62:87-99. [3] Diaz AZ. Assessment of the results from the phase Ⅰ/Ⅱ boron neutron capture therapy trials at the Brookhaven national laboratory from a clinician′s point of view. J Neurooncol,2003,62:101-109. [4] Busse PM,Harling OK,Palmer MR,et al. A critical examination of the results from the Harvard-MIT NCT program phase Ⅰ clinical trial of neutron capture therapy for intracranial disease. J Neurooncol,2003,62:111-121. [5] Kankaanranta L,Seppl T,Koivunoro H,et al. L-Boronophenylalanine-mediated boron neutron capture therapy for malignant glioma progressing after external beam radiation therapy: a phase Ⅰ study. Int J Radiati Oncol Biol Phys,2011,80:369-376. [6] Kankaanranta L,Seppl T,Koivunoro H,et al. Boron neutron capture therapy in the treatment of locally recurred head-and-neck cancer: final analysis of a phase Ⅰ/Ⅱ trial. Int J Radiat Oncol Biol Phys,2011,In Press. [7] Kawabata S,Miyatake SI,Kuroiwa T,et al. Boron neutron capture therapy for newly diagnosed glioblastoma. J Radiat Res,2009,50:51-60. [8] Miyatake SI,Kawabata S,Yokoyama K,et al. Survival benefit of boron neutron capture therapy for recurrent malignant gliomas. J Neurooncol,2009,91:199-206. [9] Coderre JA,Morris GM.The radiation biology of boron neutroncapture therapy. Radiat Res,1999,151:1-18. [10] Nigg DW. Computational dosimetry and treatment planning considerations for neutron capture therapy. J Neuro Oncol,2003,62:75-86. [11] Wittig A,Hidephery K,Paquis P,et al. Current clinical results of the EORTC-study 11961//Sauerwein W.Research and development in neutron capture therapy. Bologna: Monduzzi Editore,2002:1117-1122. [12] Harling OK. Fission reactor based epithermal neutron irradiation facilities for routine clinical application in BNCT-Hatanaka memorial lecture. Appl Radiat Isot,2009,67:7-11. [13] Yiguo L,Pu X,Xiao W,et al. Start-up of the first in-hospital neutron irradiator(IHNI-1)& presentation of the BNCT development status in China//Liberman S. New challenges in neutron capture therapy 2010:proceedings of the 14th international congress on neutron capture therapy,Buenos Aires,2010. Buenos Aires:Argentina,2010:371-374. [14] Mitsumoto T,Yajima S,Tsutsui H,et al.Cyclotron-based neutronsource for BNCT// Liberman S.New challenges in neutron capture therapy 2010:proceedings of the 14th international congress on neutron capture therapy,Buenos Aires,2010. Buenos Aires:Argentina,2010:519-522. [15] Sweet WH. Practical problems in the past in the use of boron-slow neutron capture therapy in the treatment of glioblastoma multiforme//Fairchild R. Proceedings of the first international symposium on neutron capture therapy,New York,1983. New York:INC,1983:376-378. [16] Hatanaka H,Nakagawa Y. Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy. Int J Radiat Oncol Biol Phys,1994,28:1061-1066. [17] Barth RF,Grecula JC,Yang W,et al. Combination of boron neutron capture therapy and external beam radiotherapy for brain tumors. Int J Radiat Oncol Biol Phys,2004,58:267-277. [18] Yamamoto T,Nakai K,Nariai T,et al. The status of Tsukuba BNCT trial: BPA-based boron neutron capture therapy combinedwith X-ray irradiation//Liberman S.New challenges in neutron capture therapy 2010:proceedings of the 14th international congress on neutron capture therapy,Buenos Aires,2010. Buenos Aires:Argentina,2010:7-8. [19] Henriksson R,Capala J,Michanek A,et al. Boron neutron capture therapy(BNCT) for glioblastoma multiforme:a phase Ⅱstudy evaluation a prolonged high-dose of borono phenylalanine(BPA). Radiother Oncol,2008,88:183-191. [20] Skld K,Gorlia T,Pellettieri L,et al. Boron neutron capture therapy for newly diagnosed glioblastoma multiforme: an assessment of clinical potential. Br J Radiol,2010,83:596-603. [21] Kato I,Fujita Y,Maruhashi A,et al. Effectiveness of boronneutron capture therapy for recurrent head and neck malignancies. Appl Radiat Isot,2009,67:37-42. [22] Mishima Y. Selective thermal neutron capture therapy of cancer cells using their specific metabolic activities-melanoma as prototype//Mishima Y.Cancer neutron capture therapy.New York: Plenum Press,1996:1-26. [23] Zonta A,Pinelli T,Prati U,et al. Extra-corporeal liver BNCT for the treatment of diffuse metastases: what was learned and what is still to be learned. Appl Radiat Isot,2009,67:67-75. [24] Barth RF. Boron neutron capture therapy at the crossroads:challenges and opportunities. Appl Radiat Isot,2009,67:3-6.