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精氨酸对转移性脑肿瘤放疗增敏的作用机制
刘雪萍1, 蒋雨2, 王锐锶1, 李晓春1, 谭榜宪1
1川北医学院附属医院肿瘤科,南充 637000; 2川北医学院附属医院影像科,南充 637000
Mechanism of the effect of arginine on radiosensitization of metastatic brain tumors
Liu Xueping1, Jiang Yu2, Wang Ruisi1, Li Xiaochun1, Tan Bangxian1
1Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China; 2Department of Imaging, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
Abstract：Brain metastases are the most common intracranial malignancies, and radiotherapy is an effective treatment of controlling the localized lesions. However, conventional radiotherapy techniques have their own shortcomings that limit the effectiveness of radiotherapy. Metastatic brain tumors are highly likely to recur or progress after treatment. Clinical studies have shown that arginine can penetrate the blood-brain barrier and subsequently improve the radiosensitization of metastatic brain tumors. In this article, the mechanisms underlying the effect of arginine on the radiosensitization of metastatic brain tumors by inhibition of tumor glycolytic metabolism, reduction of DNA damage repair and alteration of tumor hemodynamic parameters were reviewed, aiming to provide new ideas for clinical research and treatment of brain metastases.
Liu Xueping,Jiang Yu,Wang Ruisi et al. Mechanism of the effect of arginine on radiosensitization of metastatic brain tumors[J]. Chinese Journal of Radiation Oncology, 2023, 32(7): 657-662.
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2023, Vol. 32 
