Neck contour changes and relevant factors in nasopharyngeal carcinoma patients treated with helical tomotherapy
He Huilang1, Chen Shuxian2, Chen Xuanguang1, Zhang Zixian1, Liu Jindi1, Yao Wenyan1, Liu hui1
1Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China; 2Department of Radiation Oncology, Southern Theater Air Force Hospital, Guangzhou 510602, China
Abstract：Objective To study the change pattern of neck diameter and relevant factors in nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy, aiming to provide reference for clinical practice. Methods Fifteen NPC patients treated with helical tomotherapy at Sun Yat-Sen University Cancer Center from November 2020 to February 2021 were enrolled in this study. The transverse diameters of NPC patients' neck contours and body weight of all patients during radiotherapy were recorded weekly. We used descriptive statistics to explore the distribution of transverse diameters of NPC patients' neck contours during radiotherapy. And Spearman correlation analysis was used to assess the association between weight loss and changes in neck contour transverse diameter. Results During radiotherapy, the distribution of transverse diameters of NPC patients' neck contours was completely different from the initial values. Specifically, the transverse diameters were significantly reduced at the 4th week of the radiotherapy. Moreover, the reduction of transverse diameter of neck contour was highly correlated with the weight loss (r=0.803, P<0.05), and moderately correlated with gender (r=0.523, P<0.05). However, there was no statistical correlation between the alteration of neck diameter and age, TNM stage, and the mean dose of GTVnd-L, GTVnd-R, PTVnd-L and PTVnd-R (all P>0.05). Conclusions The neck contours of NPC patients are altered regularly during helical tomotherapy, which are narrowed the most obviously in the 4th week. Extensive attention should be paid to the changes of neck contour during radiotherapy in clinical practice.
He Huilang,Chen Shuxian,Chen Xuanguang et al. Neck contour changes and relevant factors in nasopharyngeal carcinoma patients treated with helical tomotherapy[J]. Chinese Journal of Radiation Oncology, 2023, 32(2): 106-110.
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2023, Vol. 32 
