Verification of the range calculation accuracy of a commercial proton treatment planning system
Sun Xiangshang1,2, Pu Yuehu3, Liao Wentao1,2, Kong Haiyun1, Chen Mei4, Wu Chao5, Yan Nan1,2, An Chaofan1,2, Liu Junya1,2
1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; 2University of Chinese Academy of Sciences, Beijing 100049, China; 3Medical Equipment Innovation Research Center, West China Hospital, Sichuan University, Chengdu 610041, China; 4Department of Radiotherapy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 5Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China
Abstract:Objective In Shanghai Advanced Proton Therapy Facility (SAPT) of Ruijin Hospital Proton Therapy Center, the calculation accuracy of the commercial proton treatment planning system RayStation (V10), especially the accuracy of the proton range calculation, was measured and verified, aiming to provide reference for the clinical application of the treatment planning system. Methods A head phantom was used to verify the calculation accuracy of RayStation. The phantom CT was imported into treatment planning system (TPS). The phantom was followed closely by a water tank with a one-liter cubic target. A single field verification plan with the prescribed dose of 200 cGy (relative biological effectiveness) was designed and implemented. Then, the measured distribution results were compared with the calculation results. Results When the verification plan of the phantom was designed with the default settings of RayStation, the measured longitudinal dose distribution was approximately 4 mm deeper than that of TPS, indicating that RayStation overestimated the water equivalent thickness (WET) of the tissue substitute materials in the phantom. To study the range error, the actual beam was used to measure the WET of the soft tissue substitute material. The default setting of RayStation was fine-tuned according to the measured results. It was found that the error between the measured SOBP and TPS calculations was reduced to only 2 mm. Conclusions Using the default setting of RayStation to calculate the stopping power of the phantom may cause a large range error. A method that combines tissue segmentation with the measured WET of the tissue substitute material is proposed to improve the range calculation accuracy of the TPS. The results show that the proposed method can improve the dose and range accuracy of the commercial TPS including RayStation for tissue substitute materials.
Sun Xiangshang,Pu Yuehu,Liao Wentao et al. Verification of the range calculation accuracy of a commercial proton treatment planning system[J]. Chinese Journal of Radiation Oncology, 2022, 31(11): 1028-1033.
[1] Paganetti H.Proton Beam Therapy[M]. London: Physics World Discovery, 2017: 25-29. [2] Schaffner B, Pedroni E.The precision of proton range calculations in proton radiotherapy treatment planning: experimental verification of the relation between CT-HU and proton stopping power[J]. Phys Med Biol, 1998,43(6):1579-1592. DOI: 10.1088/0031-9155/43/6/016. [3] Lomax AJ, Boehringer T, Coray A, et al.Intensity modulated proton therapy: a clinical example[J]. Med Phys, 2001,28(3):317-324. DOI: 10.1118/1.1350587. [4] Schneider U, Pedroni E, Lomax A.The calibration of CT Hounsfield units for radiotherapy treatment planning[J]. Phys Med Biol, 1996,41(1):111-124. DOI: 10.1088/0031-9155/41/1/009. [5] Rietzel E, Schardt D, Haberer T.Range accuracy in carbon ion treatment planning based on CT-calibration with real tissue samples[J]. Radiat Oncol, 2007,2:14. DOI: 10.1186/1748-717X-2-14. [6] Dietlicher I, Casiraghi M, Ares C, et al.The effect of surgical titanium rods on proton therapy delivered for cervical bone tumors: experimental validation using an anthropomorphic phantom[J]. Phys Med Biol, 2014,59(23):7181-7194. DOI: 10.1088/0031-9155/59/23/7181. [7] Lomax A.Intensity modulation methods for proton radiotherapy[J]. Phys Med Biol, 1999,44(1):185-205. DOI: 10.1088/0031-9155/44/1/014. [8] Liu W, Zhang X, Li Y, et al.Robust optimization of intensity modulated proton therapy[J]. Med Phys, 2012,39(2):1079-1091. DOI: 10.1118/1.3679340. [9] Unkelbach J, Bortfeld T, Martin BC, et al.Reducing the sensitivity of IMPT treatment plans to setup errors and range uncertainties via probabilistic treatment planning[J]. Med Phys, 2009,36(1):149-163. DOI: 10.1118/1.3021139. [10] Unkelbach J, Chan TC, Bortfeld T.Accounting for range uncertainties in the optimization of intensity modulated proton therapy[J]. Phys Med Biol, 2007,52(10):2755-2773. DOI: 10.1088/0031-9155/52/10/009. [11] International Commission on Radiation Units. Tissue substitute in radiation dosimetry and measurement[R/OL]. (1989-01-15)[2021-12-23]. https://www.osti.gov/biblio/10102048. [12] Radiology Support Device I. Head phantom with cervical spine[EB/OL].[2021-12-23]. https://rsdphantoms.com/our-products/. [13] RaySearch L. RayStation 10A reference manual[EB/OL].[2021-12-23]. https://www.raysearchlabs.com/. [14] Saini J, Maes D, Egan A, et al.Dosimetric evaluation of a commercial proton spot scanning Monte-Carlo dose algorithm: comparisons against measurements and simulations[J]. Phys Med Biol, 2017,62(19):7659-7681. DOI: 10.1088/1361-6560/aa82a5. [15] Molinelli S, Russo S, Magro G, et al.Impact of TPS calculation algorithms on dose delivered to the patient in proton therapy treatments[J]. Phys Med Biol, 2019,64(7):075016. DOI: 10.1088/1361-6560/ab0a4d. [16] 国家食品药品监督管理总局.国家食品药品监督管理总局关于发布质子/碳离子治疗系统等3个医疗器械技术审查指导原则的通告[A/OL].(2016-01-12)[2021-12-15].https://www.nmpa.gov.cn/directory/web/nmpa/xxgk/ggtg/qtggtg/20160112133401450.html. [17] Schulte R, Bashkirov V, Li TF, et al.Conceptual design of a proton computed tomography system for applications in proton radiation therapy[J]. IEEE T Nucl Sci, 2004. 51(3):866-872.DOI: 10.1109/tns.2004.829392. [18] Schneider U, Pedroni E.Proton radiography as a tool for quality control in proton therapy[J]. Med Phys, 1995,22(4):353-363. DOI: 10.1118/1.597470. [19] 崔相利, Kyungwook Jee, 王宏志, 等. 质子放疗中CT值到相对阻止本领转换关系依赖因素研究及其在脂肪区的改进[J]. 中华放射医学与防护杂志,2019,39(10): 772-777. DOI: 10.3760/cma.j.issn.0254-5098.2019.10.011. Cui XL, Jee K, Wang HZ, et al.Study on the conversion between CT hounsfield units and relative stopping power in proton therapy and the improvement in adipose tissue[J]. Chin J Radiol Med Prot, 2019,39(10):772-777.DOI: 10.3760/cma.j.issn.0254-5098.2019.10.011.