ctDNA在非小细胞肺癌放射治疗中的应用进展

doi:10.3760/cma.j.cn113030-20201127-00575

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摘要循环肿瘤DNA（ctDNA）以其无创检测、克服肿瘤异质性等优点,已成为无创液体活检最为常用的分析指标。肺癌是全世界发病率和死亡率最高的恶性肿瘤,其中约85%为非小细胞肺癌（NSCLC）。放射治疗在NSCLC各个分期中应用广泛,其直接杀死肿瘤细胞根治癌症的同时,间接增加ctDNA释放,提高液体活检准确性。因此ctDNA在NSCLC放射治疗中的应用前景广阔。本文将对ctDNA用于NSCLC放疗患者诊断、预后评估、复发监测以及疗效预测各领域的新进展进行综述。

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	杨银
	张涛
	毕楠

关键词 ：循环肿瘤DNA, 癌,非小细胞肺, 放射疗法

Abstract：Circulating tumor DNA (ctDNA) has been the most common biomarker in liquid biopsy because of non‐invasive detection and overcoming intratumor heterogeneity. Lung cancer remains the leading cause of cancer‐related morbidity and mortality all over the world, with non‐small cell lung cancer (NSCLC) constituting 85% of the total cases. Radiotherapy plays an important role in phase Ⅰ‐Ⅳ NSCLC. It can not only kill tumor cells to eradicate cancer directly, but also increase the release of ctDNA indirectly, which improves the accuracy of liquid biopsy. As a result, ctDNA has the potential to be widely used in radiotherapy for NSCLC. In this review, research progress on ctDNA in the diagnosis, prognosis assessment, recurrence detection and response prediction in NSCLC patients treated with radiotherapy were summarized.

Key words： Circulating tumor DNA Carcinoma,non‐small‐cell lung Radiotherapy

收稿日期: 2020-11-27

基金资助:中国医学科学院肺癌转化研究重点实验室基金（2018PT31035）

通讯作者: 毕楠,Email：binan_email@163.com

引用本文:

杨银,张涛,毕楠. ctDNA在非小细胞肺癌放射治疗中的应用进展[J]. 中华放射肿瘤学杂志, 2022, 31(9): 838-842.

Yang Yin,Zhang Tao,Bi Nan. Advances in application of ctDNA in radiotherapy for non‐small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(9): 838-842.

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