Quality of life in patients with early‐stage extra‐nodal NK/T cell lymphoma of nasal type after definitive radiation therapy
Li Yimin1,2, Zhang Yujing2, Li Yiyang2,3, Ye Yuming4, Zhang Yuetong2, Wang Jijin2, Wang Hanyu2
1Department of Radiation Oncology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China; 2Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Collaborative Innovation, Sun Yat‐sen University Cancer Center, Guangzhou 510000, China; 3Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510000, China; 4Department of Pneumology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China
Abstract：Objective To investigate the quality of life in patients with early‐stage extra‐nodal NK/T cell lymphoma of nasal type (ENKTL) arising from the upper aerodigestive tract, who had remained progression‐free survival (PFS) for over 3 months after definitive intensity‐modulated radiation therapy (IMRT), and to analyze the factors related to main adverse symptoms. Methods 276 patients who received IMRT from March, 2012 to June, 2021 were included. There were 201 males and 75 females with a median age of 41.5 years (range: 13‐81 years) upon diagnosis. Consistent target delineation schemes and similar dose gradients were adopted for IMRT, with a median prescribed dose of 54.6 Gy/26F. Cross‐sectional investigation was performed with a modified EORTC QLQ‐H&N35 questionnaire, the incidence and severity of adverse symptoms, severity of disease and their influencing factors at each time‐point during their survival were statistically analyzed. Results The median age of patients at the investigation was 46.2 years, and the median PFS after IMRT was 47.2 months (range: 3.1‐115.7 months). The most common adverse symptoms included nasal symptoms (incidence rate 63.8%), dry mouth (50%), tooth diseases (47.1%), smell and taste alteration, and sexual apathy, etc. Most symptoms were mild (the average standardized score was 5.50, the full score of 100 indicating the most severe), and could be relieved remarkably over survival time, but some symptoms, such as tooth diseases and sexual apathy, were more obvious and recurred for several years. Age and anti‐PD‐1 immune therapy influenced the symptom scores, and tooth diseases were closely correlated with dry mouth. Conclusion The quality of life in patients with early‐stage ENKTL after definitive IMRT is high, and the most significant symptoms include nasal symptoms, tooth diseases, and sexual apathy, etc. , which need to be mitigated with more studies.
Li Yimin,Zhang Yujing,Li Yiyang et al. Quality of life in patients with early‐stage extra‐nodal NK/T cell lymphoma of nasal type after definitive radiation therapy[J]. Chinese Journal of Radiation Oncology, 2022, 31(9): 798-804.
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